Gli1 is a potential target for alleviating multidrug resistance of gliomas

@article{Cui2010Gli1IA,
  title={Gli1 is a potential target for alleviating multidrug resistance of gliomas},
  author={Da Ming Cui and Qiwu Xu and Ke Wang and Xiaoming Che},
  journal={Journal of the Neurological Sciences},
  year={2010},
  volume={288},
  pages={156-166}
}
Although chemotherapy plays an important role in combined treatment of human gliomas, it fails to bring about satisfactory outcomes in a number of patients. One of the major obstacles in this treatment is the development of multidrug resistance (MDR) during treatment. Regulation of MDR in the context of gliomas is poorly understood, and clinical efforts to inhibit it have not been fruitful. Activation of the Hedgehog (HH) pathway has been shown to contribute to the growth, maintenance and… CONTINUE READING
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