Gli1, a potential regulator of esophageal cancer stem cell, is identified as an independent adverse prognostic factor in esophageal squamous cell carcinoma

@article{Yang2016Gli1AP,
  title={Gli1, a potential regulator of esophageal cancer stem cell, is identified as an independent adverse prognostic factor in esophageal squamous cell carcinoma},
  author={Zhaoting Yang and Penggang Liu and Weidong Ni and Seokhyung Kim and Yan-hua Xuan},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={2016},
  volume={143},
  pages={243-254}
}
The hedgehog (Hh) pathway is involved in cancer stem cell (CSC) maintenance in various tumors. Glioma-associated oncogene homolog 1 (Gli1) is a key mediator of the Hh pathway; however, its expression and clinical significance in esophageal squamous cell carcinoma (ESCC) have not been reported. In this study, we aimed to reveal clinical significance of Gli1 expression in ESCC and further investigate the potential of Gli1 as a CSC regulator of ESCC by comparing its expression with expressions of… CONTINUE READING
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