Gli1+ mesenchymal stromal cells modulate epithelial metaplasia in lung fibrosis

@article{Cassandras2019Gli1MS,
  title={Gli1+ mesenchymal stromal cells modulate epithelial metaplasia in lung fibrosis},
  author={Monica Cassandras and Chaoqun Wang and Jaymin J. Kathiriya and Tatsuya Tsukui and Peri Matatia and Michael A. Matthay and Paul J. Wolters and Ari B. Molofsky and Dean Sheppard and Hal Chapman and Tien Peng},
  journal={bioRxiv},
  year={2019}
}
Organ fibrosis is often accompanied by aberrant epithelial reprogramming, culminating in a transformed barrier composed of scar and metaplastic epithelium. Understanding how the scar promotes an abnormal epithelial response could better inform strategies to reverse the fibrotic damage. Here we show that Gli1+ mesenchymal stromal cells (MSCs), previously shown to contribute to myofibroblasts in the scar, promote metaplastic differentiation of airway progenitors into KRT5+ basal cells in vitro… 

Human alveolar Type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells

It is reported that fibrotic signalling in the lung mesenchyme leads to transdifferentiation of human alveolar type 2 cells into KRT5 + basal cells, providing a mechanistic explanation for the pathology associated with severe lung injuries.

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