Gli1+ mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung

@article{Cassandras2020Gli1MS,
  title={Gli1+ mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung},
  author={Monica Cassandras and Chaoqun Wang and Jaymin J. Kathiriya and Tatsuya Tsukui and Peri Matatia and Michael A. Matthay and Paul J. Wolters and Ari B. Molofsky and Dean Sheppard and Hal Chapman and Tien Peng},
  journal={Nature cell biology},
  year={2020},
  volume={22},
  pages={1295 - 1306}
}
Aberrant epithelial reprogramming can induce metaplastic differentiation at sites of tissue injury, culminating in transformed barriers composed of scar and metaplastic epithelium. While the plasticity of epithelial stem cells is well-characterized, the identity and role of the niche has not been delineated in metaplasia. Here we show that Gli1+ mesenchymal stromal cells (MSCs), previously shown to contribute to myofibroblasts during scarring, promote metaplastic differentiation of airway… 

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