Gli genes and limb development

  title={Gli genes and limb development},
  author={Thomas Theil and Susanne Kaesler and Lars Grotewold and Jens B{\"o}se and Ulrich U R{\"u}ther},
  journal={Cell and Tissue Research},
During development of the limb Shh plays a key role as a mediator of zone of polarizing activity (ZPA). However, the molecular mechanisms by which Shh directs anterior/posterior patterning in the limb remain unknown. Members of the Gli gene family encode zinc-finger transcription factors and represent likely candidates for being regulators of Shh target… CONTINUE READING