Gli activity correlates with tumor grade in platelet-derived growth factor-induced gliomas.

Abstract

Gli signaling is critical for central nervous system development and is implicated in tumorigenesis. To monitor Gli signaling in gliomas in vivo, we created platelet-derived growth factor-induced gliomas in a Gli-luciferase reporter mouse. We find that Gli activation is found in gliomas and correlates with grade. In addition, we find that sonic hedgehog… (More)
DOI: 10.1158/0008-5472.CAN-07-6350

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Cite this paper

@article{Becher2008GliAC, title={Gli activity correlates with tumor grade in platelet-derived growth factor-induced gliomas.}, author={Oren J. Becher and D Hambardzumyan and Elena I. Fomchenko and Hiroyuki Momota and Lori Anne Mainwaring and Anne-Marie Bleau and Amanda M. Katz and Mark A. Edgar and Anna Marie Kenney and Carlos Cordon-Cardo and Ron G Blasberg and Eric C. Holland}, journal={Cancer research}, year={2008}, volume={68 7}, pages={2241-9} }