Gli/Zic factors pattern the neural plate by defining domains of cell differentiation

  title={Gli/Zic factors pattern the neural plate by defining domains of cell differentiation},
  author={R. C. Brewster and Juliet Lee and Ariel Ruiz i Altaba},
Three cell types differentiate in the early frog neural plate: neural crest at the lateral edges, floorplate at the midline and primary neurons in three bilateral stripes. Floorplate cells and ventral neurons are induced by Sonic hedgehog, (Shh) and neural crest and dorsal neurons are induced by epidermal factors such as bone morphogenetic proteins (BMPs). Neurogenesis in a subset of cells within the stripes involves lateral inhibition. However, the process by which pools of precursors are… CONTINUE READING
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