Glaucoma-causing ADAMTS17 mutations are also reproducibly associated with height in two domestic dog breeds: selection for short stature may have contributed to increased prevalence of glaucoma

@inproceedings{Jeanes2019GlaucomacausingAM,
  title={Glaucoma-causing ADAMTS17 mutations are also reproducibly associated with height in two domestic dog breeds: selection for short stature may have contributed to increased prevalence of glaucoma},
  author={Emily C Jeanes and James A. C. Oliver and Sally L Ricketts and David J. Gould and Cathryn Mellersh},
  booktitle={Canine Genetics and Epidemiology},
  year={2019}
}
BackgroundIn humans, ADAMTS17 mutations are known to cause Weill-Marchesani-like syndrome, which is characterised by lenticular myopia, ectopia lentis, glaucoma, spherophakia, and short stature. Breed-specific homozygous mutations in ADAMTS17 are associated with primary open angle glaucoma (POAG) in several dog breeds, including the Petit Basset Griffon Vendeen (PBGV) and Shar Pei (SP). We hypothesised that these mutations are associated with short stature in these breeds.MethodsTwo hundred… CONTINUE READING
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Publications referenced by this paper.
SHOWING 1-10 OF 23 REFERENCES

The Canine Glaucomas

CE Plummer, A Regnier, KN. Gelatt
  • Gelatt KN, Gilger BC, Kern TJ, editors. Veterinary Ophthalmology
  • 2013
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

https://www.dictionary.com/browse/basset. Accessed 5 May 2019

Jeanes
  • 2019
VIEW 1 EXCERPT

physiology, anatomy and trauma

Von Pfeil DJF, DeCamp CE. The epiphyseal plate
  • Compendium. 2009;31:e1–12. Jeanes et al. Canine Genetics and Epidemiology
  • 2019
VIEW 1 EXCERPT