Glassy dynamics in the adaptive immune response prevents autoimmune disease.

@article{Sun2005GlassyDI,
  title={Glassy dynamics in the adaptive immune response prevents autoimmune disease.},
  author={Jun Sun and David J. Earl and Michael W. Deem},
  journal={Physical review letters},
  year={2005},
  volume={95 14},
  pages={148104}
}
The immune system normally protects the human host against death by infection. However, when an immune response is mistakenly directed at self-antigens, autoimmune disease can occur. We describe a model of protein evolution to simulate the dynamics of the adaptive immune response to antigens. Computer simulations of the dynamics of antibody evolution show that different evolutionary mechanisms, namely, gene segment swapping and point mutation, lead to different evolved antibody binding… CONTINUE READING

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Showing 1-10 of 16 references

Phys

  • M. W. Deem, H.-Y. Lee
  • Rev. Lett. 91, 068101
  • 2003
Highly Influential
7 Excerpts

and J

  • R. A. Goldsby, T. J. Kindt, B. A. Osborne
  • Kuby, Immunobiology
  • 2002
Highly Influential
4 Excerpts

Curr

  • M. Leirisalo-Repo
  • Opin. in Rheumatology 17, 433 5
  • 2005
1 Excerpt

Nature Med

  • M. Larché, D. C. Wraith
  • 11, S69
  • 2005
1 Excerpt

and M

  • V. Gupta, D. J. Earl
  • W. Deem
  • 2005

Physica A 350

  • T. Tan, M. W. Deem
  • 52
  • 2004
1 Excerpt

Vaccine 23

  • E. T. Muñoz, M. W. Deem
  • 1142
  • 2004
1 Excerpt

Nature Im

  • P. D. Holler, L. K. Chlewicki, D. M. Kranz
  • 4, 55
  • 2003
1 Excerpt

Evolution 55

  • M. G. Kidwell, D. R. Lisch
  • 1
  • 2001
1 Excerpt

A 30

  • M. Ney-Nifle, A. P. Young, J. Phys
  • 5311
  • 1997
1 Excerpt

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