Gitelman's syndrome with vomiting manifested by severe metabolic alkalosis and progressive renal insufficiency.

@article{Lee2013GitelmansSW,
  title={Gitelman's syndrome with vomiting manifested by severe metabolic alkalosis and progressive renal insufficiency.},
  author={Jong Ho Lee and Jeonghwan Lee and Jin Suk Han},
  journal={The Tohoku journal of experimental medicine},
  year={2013},
  volume={231 3},
  pages={165-9}
}
Gitelman's syndrome is an autosomal recessive salt-losing tubulopathy showing hypokalemic hypomagnesemic hypocalciuria with metabolic alkalosis and hyperreninemic hyperaldosteronism. This syndrome is caused by mutations in the SLC12A3 gene that encodes sodium-chloride cotransporter expressed at the apical membrane of renal distal convoluted tubule. Symptoms and renal outcomes of Gitelman's syndrome are, in general, mild and benign, and renal insufficiency from Gitelman's syndrome associated… CONTINUE READING