Ginsenoside metabolites inhibit P-glycoprotein in vitro and in situ using three absorption models.

@article{Li2014GinsenosideMI,
  title={Ginsenoside metabolites inhibit P-glycoprotein in vitro and in situ using three absorption models.},
  author={Na Li and Dandan Wang and Guangbo Ge and Xiuli Wang and Yong Liu and Ling Yang},
  journal={Planta medica},
  year={2014},
  volume={80 4},
  pages={290-6}
}
P-glycoprotein, an ATP-dependent transporter expressed in the gastrointestinal tract and tumor cells, mediates the efflux transport of multiple drugs. Inhibition or induction of P-glycoprotein by herbal ingredients can lead to herb-drug interactions and thus influence the activities of P-glycoprotein substrate drugs. The present study aimed to explore the effect of nine naturally occurring ginsenosides and their intestinal bacterial metabolites on P-glycoprotein-mediated transport. The results… CONTINUE READING

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The results showed that three ginsenoside metabolites ( CK , Ppd , and Ppt ) formed by intestinal bacteria significantly enhanced rhodamine 123 retention in Caco-2 cells , increased the absorptive permeability of rhodamine 123 , and decreased the efflux ratio of digoxin in two absorption models , which were comparable to the effects of the known P - glycoprotein inhibitor verapamil .
The results showed that three ginsenoside metabolites ( CK , Ppd , and Ppt ) formed by intestinal bacteria significantly enhanced rhodamine 123 retention in Caco-2 cells , increased the absorptive permeability of rhodamine 123 , and decreased the efflux ratio of digoxin in two absorption models , which were comparable to the effects of the known P - glycoprotein inhibitor verapamil .
The results showed that three ginsenoside metabolites ( CK , Ppd , and Ppt ) formed by intestinal bacteria significantly enhanced rhodamine 123 retention in Caco-2 cells , increased the absorptive permeability of rhodamine 123 , and decreased the efflux ratio of digoxin in two absorption models , which were comparable to the effects of the known P - glycoprotein inhibitor verapamil .
The results showed that three ginsenoside metabolites ( CK , Ppd , and Ppt ) formed by intestinal bacteria significantly enhanced rhodamine 123 retention in Caco-2 cells , increased the absorptive permeability of rhodamine 123 , and decreased the efflux ratio of digoxin in two absorption models , which were comparable to the effects of the known P - glycoprotein inhibitor verapamil .
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