Corpus ID: 2920313

Ginsenoside Rg 1 alleviates pulmonary inflammation caused by cigarette smoke-induced COPD

@inproceedings{Tao2017GinsenosideR1,
  title={Ginsenoside Rg 1 alleviates pulmonary inflammation caused by cigarette smoke-induced COPD},
  author={Yujing Tao and X. Liu and Z. Ni and Xuejun Yu},
  year={2017}
}
  • Yujing Tao, X. Liu, +1 author Xuejun Yu
  • Published 2017
  • Medicine
  • Ginsenoside Rg1, the major effective component in ginseng, has been reported to have potent antiinflammatory properties. However, the effect of Rg1 on pulmonary inflammation caused by exposure to cigarette smoke (CS) has not been investigated. In this study, we examined the molecular mechanisms underlying the effect of Rg1 on CS-induced inflammation using a mouse model. We found that inflammatory cell numbers (total cells, macrophages and neutrophils) in the bronchoalveolar lavage (BAL) fluid… CONTINUE READING

    References

    SHOWING 1-10 OF 37 REFERENCES
    Ginsenoside Rg1 improves lipopolysaccharide-induced acute lung injury by inhibiting inflammatory responses and modulating infiltration of M2 macrophages.
    • 38
    Ginsenoside Rg1 regulates innate immune responses in macrophages through differentially modulating the NF-κB and PI3K/Akt/mTOR pathways.
    • 43
    Ginsenoside Rg1 exerts synergistic anti-inflammatory effects with low doses of glucocorticoids in vitro.
    • 28
    • PDF
    Ginsenoside Rg1 improves survival in a murine model of polymicrobial sepsis by suppressing the inflammatory response and apoptosis of lymphocytes.
    • 29
    NF-κB-mediated inflammation leading to EMT via miR-200c is involved in cell transformation induced by cigarette smoke extract.
    • Yue Zhao, Y. Xu, +8 authors Qizhan Liu
    • Medicine
    • Toxicological sciences : an official journal of the Society of Toxicology
    • 2013
    • 61
    • PDF
    Ginsenoside Rg1 protects mouse liver against ischemia-reperfusion injury through anti-inflammatory and anti-apoptosis properties.
    • 48
    Ginsenoside Rg1 inhibits autophagy in H9c2 cardiomyocytes exposed to hypoxia/reoxygenation
    • 63
    Protection of ginsenoside Rg1 on chondrocyte from IL-1β-induced mitochondria-activated apoptosis through PI3K/Akt signaling
    • 43