Ginsenoside Rd prevents glutamate-induced apoptosis in rat cortical neurons.

  title={Ginsenoside Rd prevents glutamate-induced apoptosis in rat cortical neurons.},
  author={Xiao-yan Li and Jian Gang Liang and Yong-Bo Tang and Jia-guo Zhou and Yong-Yuan Guan},
  journal={Clinical and experimental pharmacology & physiology},
  volume={37 2},
1. The role of voltage-independent Ca(2+) entry in cell apoptosis has recently received considerable attention. It has been found that ginsenoside Rd significantly inhibits voltage-independent Ca(2+) entry. The aim of the present study was to investigate the protective effects of ginsenoside Rd against glutamate-induced apoptosis of rat cortical neurons. 2. Ginsenoside Rd significantly reduced glutamate-induced apoptotic morphological changes and DNA laddering. In comparison, nimodipine only… CONTINUE READING
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