Ginsenoside Rd attenuates the inflammatory response via modulating p38 and JNK signaling pathways in rats with TNBS-induced relapsing colitis.

@article{Yang2012GinsenosideRA,
  title={Ginsenoside Rd attenuates the inflammatory response via modulating p38 and JNK signaling pathways in rats with TNBS-induced relapsing colitis.},
  author={Xiao-Lai Yang and Tian-kang Guo and Yingying Wang and Yan-hui Huang and Xia Liu and Xiaoxia Wang and Wan Li and Xin Zhao and Liping Wang and Shuai Yan and Di Wu and Yong-jie Wu},
  journal={International immunopharmacology},
  year={2012},
  volume={12 2},
  pages={408-14}
}
In this study, we investigated the effects and the protective mechanism of ginsenoside Rd (GRd) which has been identified as one of the effective compounds from ginseng on relapsing colitis model induced by 2,4,6-trinitrobenzenesulfonic acid (TNBS) in rats. After inducing relapsing colitis in experimental rats on two occasions by intracolonic injection of TNBS, GRd (10, 20 and 40 mg/kg) was administered to experimental colitis rats for 7 days. The inflammatory degree was assessed by macroscopic… CONTINUE READING
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