Ginsenoside Rb1 blocks homocysteine-induced endothelial dysfunction in porcine coronary arteries.

@article{Zhou2005GinsenosideRB,
  title={Ginsenoside Rb1 blocks homocysteine-induced endothelial dysfunction in porcine coronary arteries.},
  author={Wei Zhou and Hong Chai and Peter H Lin and Alan B. Lumsden and Q. -S. Yao and Changyi Johnny Chen},
  journal={Journal of vascular surgery},
  year={2005},
  volume={41 5},
  pages={861-8}
}
OBJECTIVE Homocysteine (Hcy) is an independent risk factor for atherosclerosis. This study investigates the effects of ginsenoside Rb1, a major constituent of ginseng, on Hcy-induced endothelial dysfunction and molecular changes in porcine coronary arteries. METHODS The coronary arteries were harvested from pig hearts and cut into 5-mm ring segments, which were then divided into six groups, including control, Hcy alone (50 microM), low-dose (1 microM) or high-dose (10 microM) Rb1 alone, and… CONTINUE READING
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