Ginsenoside Rb1 and paeoniflorin inhibit transient receptor potential vanilloid-1-activated IL-8 and PGE₂ production in a human keratinocyte cell line HaCaT.

@article{Huang2010GinsenosideRA,
  title={Ginsenoside Rb1 and paeoniflorin inhibit transient receptor potential vanilloid-1-activated IL-8 and PGE₂ production in a human keratinocyte cell line HaCaT.},
  author={Jin Huang and Lei Qiu and Li Ding and Shaozhan Wang and Jing Wang and Quangang Zhu and Fengyu Song and Jinhong Hu},
  journal={International immunopharmacology},
  year={2010},
  volume={10 10},
  pages={1279-83}
}
Ginsenoside Rb1 (GRb1) and paeoniflorin (PF) are active substances of Chinese traditional herbs and have been commonly used to treat skin inflammation diseases, but little is known about the mechanisms involved. In the present study, the effects of GRb1 and PF on the production of inflammatory mediators and the possible mechanisms of transient receptor potential vanilloid-1 (TRPV1) in these mediators induction were explored. It has been shown that GRb1 and PF inhibited the productions of IL-8… CONTINUE READING

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