Ginsenoside Rb1 ameliorates lipopolysaccharide-induced albumin leakage from rat mesenteric venules by intervening in both trans- and paracellular pathway.

@article{Zhang2014GinsenosideRA,
  title={Ginsenoside Rb1 ameliorates lipopolysaccharide-induced albumin leakage from rat mesenteric venules by intervening in both trans- and paracellular pathway.},
  author={Yu Zhang and Kai Sun and Yu-ying Liu and Yun-Pei Zhang and Bai-he Hu and Xin Chang and Li Yan and Chun-shui Pan and Quan Li and Jing-yu Fan and Ke He and Xiao-Wei Mao and Lei Tu and Chuan-She Wang and Jingyan Han},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2014},
  volume={306 4},
  pages={G289-300}
}
Lipopolysaccharide (LPS) is one of the common pathogens that causes mesentery hyperpermeability- and intestinal edema-related diseases. This study evaluated whether ginsenoside Rb1 (Rb1), an ingredient of a Chinese medicine Panax ginseng, has beneficial effects on mesentery microvascular hyperpermeability induced by LPS and the underlying mechanisms. Male Wistar rats were continuously infused with LPS (5 mg · kg(-1) · h(-1)) via the left jugular vein for 90 min. In some rats, Rb1 (5 mg · kg(-1… CONTINUE READING