Ginsenoside 20(s)-Rh2 as potent natural histone deacetylase inhibitors suppressing the growth of human leukemia cells.

@article{Liu2015Ginsenoside2A,
  title={Ginsenoside 20(s)-Rh2 as potent natural histone deacetylase inhibitors suppressing the growth of human leukemia cells.},
  author={Ze-Hong Liu and Jing Li and Jing Xia and Rong Jiang and Guo-Wei Zuo and Xiao-peng Li and Yi Chen and Wei Xiong and Dongping Chen},
  journal={Chemico-biological interactions},
  year={2015},
  volume={242},
  pages={
          227-34
        }
}
BACKGROUND AND OBJECTIVE Activation and abnormal expression of histone deacetylase (HDAC) which is important target for cancer therapeutics are related to the occurrence of human leukemia. 20(s)-Ginsenoside Rh2 (20(s)-Rh2) may be a potential HDAC inhibitor (HDACi) of leukemia, but the mechanism has not been reported. METHODS The cell proliferation and apoptosis was assessed in cultured K562 and KG-1α cells. The protein expression was measured with immunoblotting. The activities of HDAC and… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-6 of 6 citations