Ginkgolides, diterpene trilactones of Ginkgo biloba, as antagonists at recombinant alpha1beta2gamma2L GABAA receptors.

@article{Huang2004GinkgolidesDT,
  title={Ginkgolides, diterpene trilactones of Ginkgo biloba, as antagonists at recombinant alpha1beta2gamma2L GABAA receptors.},
  author={Shelley H. Huang and Rujee K. Duke and Mary Chebib and Keiko Sasaki and Keiji Wada and Graham A. R. Johnston},
  journal={European journal of pharmacology},
  year={2004},
  volume={494 2-3},
  pages={131-8}
}
Ginkgolides A, B, and C are diterpene trilactones and active constituents of the 50:1 Ginkgo biloba leaf extract widely used in the symptomatic treatment of mild to moderate dementia. Using the two-electrode voltage clamp methodology, these ginkgolides were found to be moderately potent antagonists at recombinant human alpha(1)beta(2)gamma(2L) GABA(A… CONTINUE READING