Ginkgolide B prevents cathepsin-mediated cell death following cerebral ischemia/reperfusion injury.


Ginkgolide B (GB) has been shown to exert neuroprotective effects against cerebral ischemia/reperfusion (I/R) injury. However, the underlying mechanism by which GB prevents ischemic cell death remains unclear. Lysosomal proteases, including cathepsins B and L, have been implicated in ischemic cell death following reperfusion. Therefore, in the present study… (More)
DOI: 10.1097/WNR.0000000000000096