Ginkgolide A attenuates homocysteine-induced endothelial dysfunction in porcine coronary arteries.

@article{Zhou2006GinkgolideAA,
  title={Ginkgolide A attenuates homocysteine-induced endothelial dysfunction in porcine coronary arteries.},
  author={Wei Zhou and Hong Chai and Andy Courson and Peter H. Lin and Alan B. Lumsden and Qizhi Yao and Changyi Johnny Chen},
  journal={Journal of vascular surgery},
  year={2006},
  volume={44 4},
  pages={
          853-62
        }
}
BACKGROUND Homocysteine is an independent risk factor for atherosclerosis. The objective of this study was to investigate whether ginkgolide A (GA), a major constituent of Ginkgo biloba, could block homocysteine-induced endothelial dysfunction in porcine coronary arteries. METHODS Porcine coronary artery rings were assigned to six treatment groups: control; homocysteine (50 micromol/L); low-dose (50 micromol/L) or high-dose (100 micromol/L) GA; and homocysteine plus low-dose or high-dose GA… 
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