Ginkgo biloba extract regulates differentially the cell death induced by hydrogen peroxide and simvastatin.

  title={Ginkgo biloba extract regulates differentially the cell death induced by hydrogen peroxide and simvastatin.},
  author={N. Altiok and M. Ersoz and V. Karpuz and M. Koyuturk},
  volume={27 2},
  • N. Altiok, M. Ersoz, +1 author M. Koyuturk
  • Published 2006
  • Medicine, Biology
  • Neurotoxicology
  • Several human diseases have been associated with the overproduction of reactive oxygen species (ROS) and subsequently various antioxidants emerged as potential therapeutic agents that scavenge ROS. As an oxidative stress model of human disease, we used hydrogen peroxide (H2O2) to study effect of ROS on C6 glioma cells as a surrogate for astrocytes. H2O2 induced dose- and time-dependent apoptotic cell death which was preceded by growth arrest, and transiently activated the signalling proteins… CONTINUE READING
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