Ginkgo biloba extract modifies hypoglycemic action of tolbutamide via hepatic cytochrome P450 mediated mechanism in aged rats.
@article{Sugiyama2004GinkgoBE, title={Ginkgo biloba extract modifies hypoglycemic action of tolbutamide via hepatic cytochrome P450 mediated mechanism in aged rats.}, author={Tomomi Sugiyama and Yōko Kubota and Kazumasa Shinozuka and Shizuo Yamada and Jian Wu and Keizo Umegaki}, journal={Life sciences}, year={2004}, volume={75 9}, pages={ 1113-22 } }
54 Citations
Coleus forskohlii extract attenuates the hypoglycemic effect of tolbutamide in vivo via a hepatic cytochrome P450-mediated mechanism.
- Biology, ChemistryShokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan
- 2014
Results indicate that CFE induced hepatic CYPs in rats and attenuated the hypoglycemic action of tolbutamide via a hepatics CYP2C-mediated mechanism.
Effects of Ginkgo Biloba Extract on Pharmacokinetics and Pharmacodynamics of Tolbutamide and Midazolam in Healthy Volunteers
- Medicine, BiologyJournal of clinical pharmacology
- 2006
It is suggested that the combination of GBE and drugs should be cautious in terms of the potential interactions, especially in elderly patients or patients treated with drugs exerting relatively narrow therapeutic windows.
Ginkgo biloba extract attenuates warfarin-mediated anticoagulation through induction of hepatic cytochrome P450 enzymes by bilobalide in mice.
- Medicine, BiologyPhytomedicine : international journal of phytotherapy and phytopharmacology
- 2012
Herb-drug interactions: Effect of Ginkgo biloba extract on the pharmacokinetics of theophylline in rats.
- Biology, MedicineFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association
- 2007
Selective protection of curcumin against carbon tetrachloride-induced inactivation of hepatic cytochrome P450 isozymes in rats.
- Biology, ChemistryLife sciences
- 2006
[Effect of three herbal extracts on cytochrome P450 and possibility of interaction with drugs].
- Medicine, BiologyShokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan
- 2013
It is suggested that black cohosh and salacia at high dose affect the activity of hepatic CYPs, and therefore may interact with drugs that are metabolized by CYP.
Effects of ginkgo leaf tablet on the pharmacokinetics of rosiglitazone in rats and its potential mechanism
- Biology, MedicinePharmaceutical biology
- 2022
The metabolism of ROS is attenuated in the single dose of GLT by inhibiting CYP 2C8 and CYP2C9 activity, and accelerated after the multiple-dose GLT treatment, indicating that the clinical dose of ROS should be adjusted when co-administrated with GLT.
Bilobalide in ginkgo biloba extract is a major substance inducing hepatic CYPs
- Biology, ChemistryThe Journal of pharmacy and pharmacology
- 2007
It is indicated that bilobalide is the major substance in GBE that induces hepatic CYPs, and treatment with GBE and with bilobalides greatly induced pentoxyresorufin O‐dealkylase activity.
Ginkgo biloba Does Not Alter Clearance of Flurbiprofen, a Cytochrome P450‐2C9 Substrate
- MedicineJournal of clinical pharmacology
- 2006
The results confirm previous controlled clinical studies showing no effect of ginkgo on the kinetics or dynamics of warfarin, and are apparently too low to inhibit CYP2C9 function in vivo.
Effects of some commonly used Saudi folk herbal medications on the metabolic activity of CYP2C9 in human liver microsomes.
- BiologySaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society
- 2010
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