Ginkgo biloba extract modifies hypoglycemic action of tolbutamide via hepatic cytochrome P450 mediated mechanism in aged rats.

  title={Ginkgo biloba extract modifies hypoglycemic action of tolbutamide via hepatic cytochrome P450 mediated mechanism in aged rats.},
  author={Tomomi Sugiyama and Yōko Kubota and Kazumasa Shinozuka and Shizuo Yamada and Jian Wu and Keizo Umegaki},
  journal={Life sciences},
  volume={75 9},

Coleus forskohlii extract attenuates the hypoglycemic effect of tolbutamide in vivo via a hepatic cytochrome P450-mediated mechanism.

Results indicate that CFE induced hepatic CYPs in rats and attenuated the hypoglycemic action of tolbutamide via a hepatics CYP2C-mediated mechanism.

Effects of Ginkgo Biloba Extract on Pharmacokinetics and Pharmacodynamics of Tolbutamide and Midazolam in Healthy Volunteers

It is suggested that the combination of GBE and drugs should be cautious in terms of the potential interactions, especially in elderly patients or patients treated with drugs exerting relatively narrow therapeutic windows.

Ginkgo biloba extract attenuates warfarin-mediated anticoagulation through induction of hepatic cytochrome P450 enzymes by bilobalide in mice.

Herb-drug interactions: Effect of Ginkgo biloba extract on the pharmacokinetics of theophylline in rats.

[Effect of three herbal extracts on cytochrome P450 and possibility of interaction with drugs].

It is suggested that black cohosh and salacia at high dose affect the activity of hepatic CYPs, and therefore may interact with drugs that are metabolized by CYP.

Effects of ginkgo leaf tablet on the pharmacokinetics of rosiglitazone in rats and its potential mechanism

The metabolism of ROS is attenuated in the single dose of GLT by inhibiting CYP 2C8 and CYP2C9 activity, and accelerated after the multiple-dose GLT treatment, indicating that the clinical dose of ROS should be adjusted when co-administrated with GLT.

Bilobalide in ginkgo biloba extract is a major substance inducing hepatic CYPs

It is indicated that bilobalide is the major substance in GBE that induces hepatic CYPs, and treatment with GBE and with bilobalides greatly induced pentoxyresorufin O‐dealkylase activity.

Ginkgo biloba Does Not Alter Clearance of Flurbiprofen, a Cytochrome P450‐2C9 Substrate

The results confirm previous controlled clinical studies showing no effect of ginkgo on the kinetics or dynamics of warfarin, and are apparently too low to inhibit CYP2C9 function in vivo.

Effects of some commonly used Saudi folk herbal medications on the metabolic activity of CYP2C9 in human liver microsomes.

  • F. Al-Jenoobi
  • Biology
    Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society
  • 2010



Ginkgo biloba extract markedly induces pentoxyresorufin O-dealkylase activity in rats.

It is indicated that excess intake of GBE induces CYP enzymes, particularly PROD, and may modify the efficacy of drugs taken simultaneously, and the effect of Ginkgo biloba extract on hepatic drug-metabolizing enzymes,particularly cytochrome P450 (CYP), in rats.

Effects of repeated treatments with an extract of Ginkgo biloba (EGb 761) and bilobalide on liver and muscle glycogen contents in the non‐insulin‐dependent diabetic rat

The effects of repeated (15‐day) oral treatments with an extract of Ginkgo biloba or with its terpenoid constituent, bilobalide, were assessed in normal rats and in rats that had been previously injected with streptozotocin, a model of non‐insulin‐dependent diabetes mellitus (NIDDM).

Tolbutamide, Flurbiprofen, and Losartan as Probes of CYP2C9 Activity in Humans

Tlbutamide is a better CYP2C9 probe than flurbiprofen and losartan, and the 0‐ to 12‐hour amount of 4'‐hydroxytolbutamide and carboxytol butamide is the best urinary measure of its metabolism.

Efficacy, safety, and use of ginkgo biloba in clinical and preclinical applications.

Ginkgo biloba is a dioecious tree with a history of use in traditional Chinese medicine. Although the seeds are most commonly employed in traditional Chinese medicine, in recent years standardized

The Effect of 3‐Month Ingestion of Ginkgo biloba Extract (EGb 761) on Pancreatic β‐Cell Function in Response to Glucose Loading in Individuals with Non‐Insulin‐Dependent Diabetes Mellitus

  • G. Kudolo
  • Medicine, Biology
    Journal of clinical pharmacology
  • 2001
It is concluded that ingestion of Ginkgo biloba extract by an NIDDM subject may increase the hepatic metabolic clearance rate of not only insulin but also the hypoglycemic agents, resulting in reduced insulin‐mediated glucose metabolism and elevated blood glucose.

Ginkgo biloba for antidepressant-induced sexual dysfunction.

The article includes a discussion of presumed pharmacologic mechanisms, including effects on platelet activating factor, prostaglandins, peripheral vasodilatation, and central serotonin and norepinephrine receptor factor modulation.


The present paper gives a detailed account of the investigations on rabbit liver microsomes and crude microsomal digests, which have led to postulate the hemoprotein nature of the pigment.

Interactions of Warfarin with Garlic, Ginger, Ginkgo, or Ginseng: Nature of the Evidence

The true risks of these interactions and effects are difficult to characterize due to the limited number and nature of existing reports.