Ginkgo biloba extract modifies hypoglycemic action of tolbutamide via hepatic cytochrome P450 mediated mechanism in aged rats.

@article{Sugiyama2004GinkgoBE,
  title={Ginkgo biloba extract modifies hypoglycemic action of tolbutamide via hepatic cytochrome P450 mediated mechanism in aged rats.},
  author={Tomomi Sugiyama and Yōko Kubota and Kazumasa Shinozuka and Shizuo Yamada and Jian Wu and Keizo Umegaki},
  journal={Life sciences},
  year={2004},
  volume={75 9},
  pages={
          1113-22
        }
}
We examined hepatic cytochrome P450 (CYP)-mediated interactions between Ginkgo biloba extract (GBE) and tolbutamide, an oral anti-diabetic agent, in aged and young rats. Tolbutamide was orally given to rats with or without GBE treatment, and time-dependent changes in blood glucose were monitored. The basal activity of six CYP subtypes in liver was lower in the aged rats than in the young rats, while the inductions of these enzymes by 5 day pretreatment of 0.1% GBE diet were more in the aged… Expand
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