Ginkgo biloba extract modifies hypoglycemic action of tolbutamide via hepatic cytochrome P450 mediated mechanism in aged rats.

@article{Sugiyama2004GinkgoBE,
  title={Ginkgo biloba extract modifies hypoglycemic action of tolbutamide via hepatic cytochrome P450 mediated mechanism in aged rats.},
  author={Tomomi Sugiyama and Yōko Kubota and Kazumasa Shinozuka and Shizuo Yamada and Jian Wu and Keizo Umegaki},
  journal={Life sciences},
  year={2004},
  volume={75 9},
  pages={
          1113-22
        }
}
We examined hepatic cytochrome P450 (CYP)-mediated interactions between Ginkgo biloba extract (GBE) and tolbutamide, an oral anti-diabetic agent, in aged and young rats. Tolbutamide was orally given to rats with or without GBE treatment, and time-dependent changes in blood glucose were monitored. The basal activity of six CYP subtypes in liver was lower in the aged rats than in the young rats, while the inductions of these enzymes by 5 day pretreatment of 0.1% GBE diet were more in the aged… Expand
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Coleus forskohlii extract attenuates the hypoglycemic effect of tolbutamide in vivo via a hepatic cytochrome P450-mediated mechanism.
TLDR
Results indicate that CFE induced hepatic CYPs in rats and attenuated the hypoglycemic action of tolbutamide via a hepatics CYP2C-mediated mechanism. Expand
[Effects of various ginkgo biloba extracts and proanthocyanidin on hepatic cytochrome P450 activity in rats].
TLDR
It is suggested that most GBE samples available in Japan induce CYPs in rats regardless of the preparation method of the GBE, and that proanthocyanidin is not responsible for the induction. Expand
Effects of Ginkgo Biloba Extract on Pharmacokinetics and Pharmacodynamics of Tolbutamide and Midazolam in Healthy Volunteers
TLDR
It is suggested that the combination of GBE and drugs should be cautious in terms of the potential interactions, especially in elderly patients or patients treated with drugs exerting relatively narrow therapeutic windows. Expand
Ginkgo biloba extract attenuates warfarin-mediated anticoagulation through induction of hepatic cytochrome P450 enzymes by bilobalide in mice.
TLDR
GBE and ginkgolide B have no influence on blood coagulation in vivo, and that GBE attenuates the anticoagulation action of warfarin via induction of hepatic CYPs by bilobalide is suggested. Expand
Herb-drug interactions: Effect of Ginkgo biloba extract on the pharmacokinetics of theophylline in rats.
TLDR
It is demonstrated that GBE pretreatment increased CYP1A2 metabolic activity and the clearance of theophylline in rats, and an important therapeutic agent with narrow therapeutic window used for the treatment of asthma. Expand
Selective protection of curcumin against carbon tetrachloride-induced inactivation of hepatic cytochrome P450 isozymes in rats.
TLDR
Dietary intake of curcumin may protect against CCl(4)-induced hepatic CYP inactivation via its antioxidant properties, without inducing hepatic cytochrome P450 activity. Expand
[Effect of three herbal extracts on cytochrome P450 and possibility of interaction with drugs].
TLDR
It is suggested that black cohosh and salacia at high dose affect the activity of hepatic CYPs, and therefore may interact with drugs that are metabolized by CYP. Expand
Effect of Ginkgo biloba special extract EGb 761® on human cytochrome P450 activity: a cocktail interaction study in healthy volunteers
TLDR
EGb 761® has no relevant effect on the in vivo activity of the major CYP enzymes in humans and therefore has norelevant potential to cause respective metabolic drug–drug interactions. Expand
Bilobalide in ginkgo biloba extract is a major substance inducing hepatic CYPs
TLDR
It is indicated that bilobalide is the major substance in GBE that induces hepatic CYPs, and treatment with GBE and with bilobalides greatly induced pentoxyresorufin O‐dealkylase activity. Expand
Ginkgo biloba Does Not Alter Clearance of Flurbiprofen, a Cytochrome P450‐2C9 Substrate
TLDR
The results confirm previous controlled clinical studies showing no effect of ginkgo on the kinetics or dynamics of warfarin, and are apparently too low to inhibit CYP2C9 function in vivo. Expand
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References

SHOWING 1-10 OF 27 REFERENCES
Ginkgo biloba extract markedly induces pentoxyresorufin O-dealkylase activity in rats.
TLDR
It is indicated that excess intake of GBE induces CYP enzymes, particularly PROD, and may modify the efficacy of drugs taken simultaneously, and the effect of Ginkgo biloba extract on hepatic drug-metabolizing enzymes,particularly cytochrome P450 (CYP), in rats. Expand
Feeding of Ginkgo biloba extract (GBE) enhances gene expression of hepatic cytochrome P-450 and attenuates the hypotensive effect of nicardipine in rats.
TLDR
The feeding of GBE for 4 weeks significantly reduced the hypotensive effect of nicardipine that was reported to be metabolized by CYP3A2 in rats, suggesting that GBE reduces the therapeutic potency of the Ca2+ channel blocker, nicardipsine, via enhancement of cytochrome P-450 expression. Expand
Effects of repeated treatments with an extract of Ginkgo biloba (EGb 761) and bilobalide on liver and muscle glycogen contents in the non‐insulin‐dependent diabetic rat
The effects of repeated (15‐day) oral treatments with an extract of Ginkgo biloba (EGb 761; 50 mg/kg/day) or with its terpenoid constituent, bilobalide (2 mg/kg/day), were assessed in normal rats and… Expand
Tolbutamide, Flurbiprofen, and Losartan as Probes of CYP2C9 Activity in Humans
TLDR
Tlbutamide is a better CYP2C9 probe than flurbiprofen and losartan, and the 0‐ to 12‐hour amount of 4'‐hydroxytolbutamide and carboxytol butamide is the best urinary measure of its metabolism. Expand
Ethnopharmacology and the development of natural PAF antagonists as therapeutic agents.
TLDR
Ginkgolides are unique twenty-carbon terpenes, occurring naturally only in the roots and leaves of Ginkgo biloba, and are specific and potent antagonists of platelet-activating factor (PAF), a potent inflammatory autacoid. Expand
Efficacy, safety, and use of ginkgo biloba in clinical and preclinical applications.
Ginkgo biloba is a dioecious tree with a history of use in traditional Chinese medicine. Although the seeds are most commonly employed in traditional Chinese medicine, in recent years standardized… Expand
The Effect of 3‐Month Ingestion of Ginkgo biloba Extract (EGb 761) on Pancreatic β‐Cell Function in Response to Glucose Loading in Individuals with Non‐Insulin‐Dependent Diabetes Mellitus
  • G. Kudolo
  • Medicine
  • Journal of clinical pharmacology
  • 2001
TLDR
It is concluded that ingestion of Ginkgo biloba extract by an NIDDM subject may increase the hepatic metabolic clearance rate of not only insulin but also the hypoglycemic agents, resulting in reduced insulin‐mediated glucose metabolism and elevated blood glucose. Expand
Ginkgo biloba for antidepressant-induced sexual dysfunction.
TLDR
The article includes a discussion of presumed pharmacologic mechanisms, including effects on platelet activating factor, prostaglandins, peripheral vasodilatation, and central serotonin and norepinephrine receptor factor modulation. Expand
THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE.
TLDR
The present paper gives a detailed account of the investigations on rabbit liver microsomes and crude microsomal digests, which have led to postulate the hemoprotein nature of the pigment. Expand
Interactions of Warfarin with Garlic, Ginger, Ginkgo, or Ginseng: Nature of the Evidence
TLDR
The true risks of these interactions and effects are difficult to characterize due to the limited number and nature of existing reports. Expand
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