Ginkgo biloba extract-induced relaxation of rat aorta is associated with increase in endothelial intracellular calcium level.

@article{Kubota2001GinkgoBE,
  title={Ginkgo biloba extract-induced relaxation of rat aorta is associated with increase in endothelial intracellular calcium level.},
  author={Yōko Kubota and Naoko Tanaka and Keizo Umegaki and H Takenaka and Hideya Mizuno and K. Nakamura and Kazumasa Shinozuka and Masaru Kunitomo},
  journal={Life sciences},
  year={2001},
  volume={69 20},
  pages={
          2327-36
        }
}
Effects of Ginkgo biloba extract feeding on salt-induced hypertensive Dahl rats.
TLDR
It is demonstrated that GBE reduced salt-related elevation of blood pressure and restored the impaired acetylcholine-induced vasodilation in aortic segments.
Effects of quercetin and rutin on vascular preparations
TLDR
The mechanical and electrophysiological properties of quercetin and its rutoside, rutin, are investigated in an attempt to clarify how Ca2+ channel activation might be related to the myorelaxing activity.
Effects of Ginkgo biloba extract on blood pressure and vascular endothelial response by acetylcholine in spontaneously hypertensive rats
TLDR
The results suggested that Ginkgo enhanced endothelium‐dependent vasodilation and elevation of the endothelial intracellular Ca2+ level in SHR, resulting in hypotension, and was associated with restoration of impaired dilatory function induced by acetylcholine in endothelial cells.
Study on mechanism of vasorelaxatory effect of Vitis vinifera leaf extract in rat aorta
TLDR
The results suggest that Vitis vinifera leaf hydroalcoholic extract induces relaxation in rat aorta possibly by opening the Ca 2+ -operated K + channels but, not ATP- sensitive K + channel and extracellular calcium was essential for inducing vasorelaxation by extract.
Activity of Ginkgo biloba extract and quercetin on thrombomodulin expression and tissue-type plasminogen activator secretion by human umbilical vein endothelial cells.
TLDR
The effect of GBE on improving blood circulation may be partly attributed to its promoting TM expression and t-PA secretion by endothelial cells, and quercetin participated in the effect of EMT in a dose- and time-dependent manner.
VASORELAXATORY EFFECT OF VITIS VINIFERA EXTRACT ON RAT AORTA
TLDR
The results suggest that the greatest vasorelaxant effect of VHLE on rat aorta is endotheliumdependent and nitric oxide (NO) and cGMP are mostly responsible but cholinergic receptors are not involved.
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