Ginkgo biloba extract attenuates warfarin-mediated anticoagulation through induction of hepatic cytochrome P450 enzymes by bilobalide in mice.

@article{Taki2012GinkgoBE,
  title={Ginkgo biloba extract attenuates warfarin-mediated anticoagulation through induction of hepatic cytochrome P450 enzymes by bilobalide in mice.},
  author={Y. Taki and Kaori Yokotani and S. Yamada and K. Shinozuka and Y. Kubota and Yasuo Watanabe and K. Umegaki},
  journal={Phytomedicine : international journal of phytotherapy and phytopharmacology},
  year={2012},
  volume={19 2},
  pages={
          177-82
        }
}
Ginkgo biloba extract (GBE) is a popular herbal ingredient used worldwide, but it is reported to induce bleeding as a serious adverse event. In this study we examined whether GBE induced spontaneous bleeding or accelerated warfarin anticoagulation via herb-drug interaction. Mice were given GBE or various active components of GBE orally for 5 days and blood coagulation parameters and hepatic cytochrome P450 enzymes (CYPs) were measured. Mice also received warfarin (racemate, (S)- or (R… Expand
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