Ginkgo biloba extract attenuates warfarin-mediated anticoagulation through induction of hepatic cytochrome P450 enzymes by bilobalide in mice.

  title={Ginkgo biloba extract attenuates warfarin-mediated anticoagulation through induction of hepatic cytochrome P450 enzymes by bilobalide in mice.},
  author={Yuko Taki and Kaori Yokotani and Shizuo Yamada and Kazumasa Shinozuka and Yōko Kubota and Yasuo Watanabe and Keizo Umegaki},
  journal={Phytomedicine : international journal of phytotherapy and phytopharmacology},
  volume={19 2},
  • Y. Taki, Kaori Yokotani, K. Umegaki
  • Published 15 January 2012
  • Medicine, Biology, Chemistry
  • Phytomedicine : international journal of phytotherapy and phytopharmacology

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Pretreatment with Ginkgo biloba extract weakens the hypnosis action of phenobarbital and its plasma concentration in rats
GBE reduces the therapeutic potency of phenobarbital via enhancement of cytochrome P450 expression, and raises the possibility that GBE and drug interactions may occur clinically.
Bilobalide in ginkgo biloba extract is a major substance inducing hepatic CYPs
It is indicated that bilobalide is the major substance in GBE that induces hepatic CYPs, and treatment with GBE and with bilobalides greatly induced pentoxyresorufin O‐dealkylase activity.
Induction of propranolol metabolism by Ginkgo biloba extract EGb 761 in rats.
Results indicated that EGb 761 pretreatment decreased the plasma concentrations of propranolol by accelerated conversion of parental drug to NDP due to induction of CYP1A2.
Comparison of the anticoagulant and antithrombotic effects of YM-75466, a novel orally-active factor Xa inhibitor, and warfarin in mice.
It is shown that YM-75466 has advantages over warfarin: i) rapid onset of anticoagulant activity, ii) wide therapeutic range, iii) little effect on bleeding and iv) lack of drug interaction with agents that interfere withwarfarin.
Interaction of Ginkgo biloba extract (GBE) with hypotensive agent, nicardipine, in rats.
It is suggested that GBE attenuated the therapeutic potency of nicardipine, probably secondary to increased hepatic drug metabolism.
Warfarin Withdrawal
Oral anticoagulant therapy with warfarin or other coumarin derivatives is increasingly administered to patients for primary or secondary prevention of various arterial or venous thromboembolic diseases, confirming that withdrawal from OAT is an occurrence that affects a large number of patients.
[Effect of Coenzyme Q10 and Ginkgo biloba on warfarin dosage in patients on long-term warfarin treatment. A randomized, double-blind, placebo-controlled cross-over trial].
The study indicated that Coenzyme Q10 and Ginkgo biloba do not influence the clinical effect of warfarin.
Investigation of the Effects of Herbal Medicines on Warfarin Response in Healthy Subjects: A Population Pharmacokinetic‐Pharmacodynamic Modeling Approach
None of the herbs studied had a direct effect on warfarin pharmacodynamics, and studies in anticoagulated patients are warranted to assess the clinical significance of these herb‐drug interactions.