Ginkgo biloba extract attenuates the disruption of pro-and anti-inflammatory T-cell balance in peripheral blood of arsenicosis patients

@article{Xia2020GinkgoBE,
  title={Ginkgo biloba extract attenuates the disruption of pro-and anti-inflammatory T-cell balance in peripheral blood of arsenicosis patients},
  author={S. Xia and Qian Sun and Z. Zou and Yonglian Liu and X. Fang and Baofei Sun and Shaofeng Wei and Dapeng Wang and Ai-hua Zhang and Qizhan Liu},
  journal={International Journal of Biological Sciences},
  year={2020},
  volume={16},
  pages={483 - 494}
}
Endemic arsenicosis is a public health problem that affects thousands of people worldwide. However, the biological mechanism involved is not well characterized, and there is no specific treatment. Exposure to arsenic may be associated with immune-related problems. In the present work, we performed an investigation to determine whether the Th17/Treg balance was abnormal in peripheral blood mononuclear cells (PBMCs) of patients with arsenicosis caused by burning coal. Furthermore, we investigated… Expand
3 Citations
Imbalanced inflammatory response in subchronic arsenic‐induced liver injury and the protective effects of Ginkgo biloba extract in rats: Potential role of cytokines mediated cell–cell interactions
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It is concluded that the disruption of pro- and anti-inflammatory T-cells balance caused by cytokines mediated cell-cell interactions may be one of the mechanisms underlying arsenic-induced liver injury and that GBE intervention exerts an evidence protective effects, which might be closely associated with the suppression of inflammatory-related TLR4 pathway. Expand
Defining IL‐6 levels in healthy individuals: A meta‐analysis
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A meta‐analysis on a total of 140 studies, including 12,421 values for IL‐6 in the blood of healthy adult donors, found that among these studies, 83 did not report a mean value and the standard deviation, and used the values reported in 57 studies, which included 3166 values forIL‐6. Expand
Assessing the risk of coal-burning arsenic-induced liver damage: a population-based study on hair arsenic and cumulative arsenic
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Scientific insight is provided into understanding the dose-response relationship of liver damage caused by coal-burning arsenic exposure and the monitoring and prevention of arsenic poisoning. Expand

References

SHOWING 1-10 OF 78 REFERENCES
Ginkgo biloba extract EGb 761 has anti-inflammatory properties and ameliorates colitis in mice by driving effector T cell apoptosis.
TLDR
It is shown that EGb 761 suppresses the activation of macrophages and can be used to both prevent and treat mouse colitis, and drives CD4+ effector T cell apoptosis in vitro and in vivo, providing a mechanistic explanation to the reduction in numbers of this cell type in the colon. Expand
Effect of Arsenic on Regulatory T Cells
TLDR
The data indicate that As seems to have a relevant and complex effect on T regulatory cells, and in 47 apparently healthy subjects chronically exposed to As, significant inverse correlation between urinary As levels and the number and function of nTreg lymphocytes is found. Expand
Ginkgo biloba extracts attenuate lipopolysaccharide-induced inflammatory responses in acute lung injury by inhibiting the COX-2 and NF-κB pathways.
TLDR
The results indicated that G. biloba extract has a protective effect on LPS-induced acute lung injury in mice, and the protective mechanism may be partly attributed to the inhibition of NF-κB p65 and COX-2 activation. Expand
Inorganic arsenic represses interleukin-17A expression in human activated Th17 lymphocytes.
TLDR
It is demonstrated that As(III) represses expression of the major pro-inflammatory cytokine IL-17A produced by human Th17 lymphocytes, thus strengthening the idea that As (III) may be useful to treat inflammatory immune-mediated diseases in humans. Expand
Imbalanced immune responses involving inflammatory molecules and immune‐related pathways in the lung of acute and subchronic arsenic‐exposed mice
TLDR
Both acute and subchronic oral administration of arsenic triggers multiple pulmonary immune responses involving inflammatory molecules and T‐cell differentiation, which might be closely associated with the imbalanced redox status and activation of immune‐related MAPKs, NF‐&kgr;B and anti‐inflammatory NRF2 pathways. Expand
Protective effect of Ginkgo biloba leaves extract, EGb761, on endotoxin-induced acute lung injury via a JNK- and Akt-dependent NFκB pathway.
TLDR
EGb761 is a potential protective agent for ALI, possibly via downregulating the JNK- and Akt-dependent NFκB activation pathway. Expand
Effect of Ginkgo biloba extract, EGb 761, on the cellular immune response in a hypothalamic-pituitary-adrenal axis activation model in the rat.
TLDR
It is indicated that the phytopharmaceutical EGb 761 possesses immunostimulatory properties and has stress-alleviating properties through its moderation of corticosterone levels, and possesses antioxidant activity that may contribute to its effects on the immune response. Expand
The mechanistic basis of arsenicosis: pathogenesis of skin cancer.
TLDR
Arsenic mediates its toxicity by generating oxidative stress, causing immune dysfunction, promoting genotoxicity, hampering DNA repair, and disrupting signal transduction, which may explain the complex disease manifestations seen in arsenicosis. Expand
Low-level arsenic causes chronic inflammation and suppresses expression of phagocytic receptors
TLDR
It is indicated that chronic low-level As exposure not only evoked chronic inflammatory changes but also suppressed the expression of FcγRs and CRs in the exposed women, which may lead to susceptibility towards pathogenic infections or in long run contribute towards chronic inflammatory diseases including cancer. Expand
Effects of Ginkgo biloba extract on expressions of IL-1beta, TNF-alpha, and IL-10 in U937 foam cells.
TLDR
GbE inhibited production of pro- inflammatory cytokines IL-1beta and TNF-alpha, but up-regulated the production of anti-inflammatory cytokine IL-10 and its receptor IL- 10R in U937 foam cells, which might be related with its anti-atherosclerotic actions. Expand
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