Ginkgo biloba extract (GbE) enhances the anti-atherogenic effect of cilostazol by inhibiting ROS generation

@article{Jung2012GinkgoBE,
  title={Ginkgo biloba extract (GbE) enhances the anti-atherogenic effect of cilostazol by inhibiting ROS generation},
  author={In-Hyuk Jung and You-Han Lee and Ji Young Yoo and Se-Jin Jeong and Seong Keun Sonn and Jong-Gil Park and Keun Ho Ryu and Bongyong Lee and Hye Young Han and So Young Lee and Dae Yong Kim and Hang-Do Lee and Goo Taeg Oh},
  journal={Experimental \& Molecular Medicine},
  year={2012},
  volume={44},
  pages={311 - 318}
}
  • I. JungYou-Han Lee G. Oh
  • Published 27 January 2012
  • Biology, Chemistry
  • Experimental & Molecular Medicine
In this study, the synergistic effect of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl) butoxy]-3,4-dihydro-2(1H)-quinolinone (cilostazol) and Ginkgo biloba extract (GbE) was examined in apolipoprotein E (ApoE) null mice. Co-treatment with GbE and cilostazol synergistically decreased reactive oxygen species (ROS) production in ApoE null mice fed a high-fat diet. Co-treatment resulted in a significantly decreased atherosclerotic lesion area compared to untreated ApoE mice. The inflammatory cytokines and… 
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