Ginkgo biloba extract (EGb 761) and CNS functions: basic studies and clinical applications.
@article{Defeudis2000GinkgoBE, title={Ginkgo biloba extract (EGb 761) and CNS functions: basic studies and clinical applications.}, author={Francis V. Defeudis and Katy Drieu}, journal={Current drug targets}, year={2000}, volume={1 1}, pages={ 25-58 } }
The effects of EGb 761 on the CNS underlie one of its major therapeutic indications; i.e., individuals suffering from deteriorating cerebral mechanisms related to age-associated impairments of memory, attention and other cognitive functions. [] Key Result Both flavonoid and ginkgolide constituents are involved in the free radical-scavenging and antioxidant effects of EGb 761 which decrease tissue levels of reactive oxygen species (ROS) and inhibit membrane lipid peroxidation.
407 Citations
Benefits of Treatment with Ginkgo Biloba Extract EGb 761 Alone or Combined with Acetylcholinesterase Inhibitors in Vascular Dementia
- Psychology, MedicineClinical Drug Investigation
- 2022
After 12 months of treatment EGb 761 alone or combined with AChEI showed cognitive and behavioral benefits in patients suffering from VaD, providing additional real-world evidence for the combined use of EGb 661 and anti-dementia drugs in VaD patients.
Neural and Behavioural Effects of the Ginkgo biloba Leaf Extract Egb 761
- Biology, Psychology
- 2009
The possible neurogenic-enhancing effects of Ginkgo on adult hippocampal neurogenesis as a possible mechanism underlying its nootropic effects have not been evaluated, and experiments discussed in the present thesis assessed such a possibility.
Neuroprotective and Antioxidant Effect of Ginkgo biloba Extract Against AD and Other Neurological Disorders
- BiologyNeurotherapeutics
- 2019
This review summarizes recent advancements in understanding of the potential use of Ginkgo biloba extract in the prevention of AD including its antioxidant property.
Ginkgo biloba (EGb 761): A Proprietary Leaf Extract of Ginkgo biloba Is Found to be Safe and Effective for Treating Dementia.
- Medicine, BiologyHolistic nursing practice
- 2015
According to the World Health Ginkgo biloba EGb 761 leaf extract is widely prescribed to improve cognitive function in cases of age-related dementia. Organization, the number of individuals living…
Effects of Ginkgo biloba extract (EGb 761) on gene expression: Possible relevance to neurological disorders and age‐associated cognitive impairment
- Biology
- 2002
Results indicate that the therapeutic effects of EGb 761 on cognitive impairment (dementia) may involve its action of altering gene expression, and a fundamental mechanism that may underlie EGb 661‐induced neuroprotection is identified.
The Use of Ginkgo Biloba L. as a Neuroprotective Agent in the Alzheimer’s Disease
- BiologyFrontiers in Pharmacology
- 2021
By exploring more about the pathogenesis of the disease and the benefits of G. biloba extract for patients with Alzheimer’s disease, it will be possible to create an individualized therapeutic protocol to optimize the treatment.
Protective effects of bilobalide on Aβ25–35 induced learning and memory impairments in male rats
- Biology, ChemistryPharmacology Biochemistry and Behavior
- 2013
Long-term treatment with Ginkgo biloba extract EGb 761 improves symptoms and pathology in a transgenic mouse model of Alzheimer’s disease
- BiologyBrain, Behavior, and Immunity
- 2015
Antioxidant properties of a Ginkgo biloba leaf extract (EGb 761) in animal models of Alzheimer's and Parkinson's diseases
- Biology
- 2016
Preclinical studies performed both in vitro and in vivo of Alzheimer ́s and Parkinson’s diseases, shows that EGb761 produces neuroprotective/antioxidant effect.
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