Ginkgo biloba attenuates aluminum lactate-induced neurotoxicity in reproductive senescent female rats: behavioral, biochemical, and histopathological study

  title={Ginkgo biloba attenuates aluminum lactate-induced neurotoxicity in reproductive senescent female rats: behavioral, biochemical, and histopathological study},
  author={Sonia Verma and Pavitra Ranawat and Neha Sharma and Bimla Nehru},
  journal={Environmental Science and Pollution Research},
  pages={27148 - 27167}
Extensive use of aluminum (Al) in industry, cooking utensils, and wrapping or freezing the food items, due to its cheapness and abundance in the environment, has become a major concern. Growing evidence supports that environmental pollutant Al promotes the aggregation of amyloid beta (Aβ) in the brain, which is the main pathological marker of Alzheimer’s disease (AD). Further, AD- and Al-induced neurotoxic effects are more common among women following reproductive senescence due to decline in… Expand
Modulatory Effects of Ginkgo biloba Against Amyloid Aggregation Through Induction of Heat Shock Proteins in Aluminium Induced Neurotoxicity
Results indicate that GBE prevents the symptoms of Al induced AD like pathophysiology by upregulating the HSPs levels and decreasing the aggregation load. Expand
Studies on the Neuromodulatory Effects of Ginkgo biloba on Alterations in Lipid Composition and Membrane Integrity of Rat Brain Following Aluminium Neurotoxicity
Results showed that pretreatment with GBE provided more beneficial effects on the adverse changes following Al in membrane composition and behavioral outcome, which however were normalized following GBE supplementation. Expand
Ginkgo biloba attenuated hepatotoxicity induced by combined exposure to cadmium and fluoride via modulating the redox imbalance, Bax/Bcl-2 and NF-kB signaling pathways in male rats.
Interestingly, G.B alleviated F + Cd induced liver oxidative stress, mitochondrial damage and prevented inflammation and apoptosis and decrease in serum liver enzymes and improvement of histopathologic lesions were observed in G. B treated rats. Expand
Ginkgo biloba Extract Attenuates Methotrexate-Induced Testicular Injury in Rats: Cross-talk Between Oxidative Stress, Inflammation, Apoptosis, and miRNA-29a Expression
GIN could protect against MTX-induced gonadotoxicity by its antioxidant, anti-inflammatory, antiapoptotic activities plus the regulation of the miRNA-29a testicular expression. Expand
Aluminum-Induced Synaptic Plasticity Impairment via PI3K-Akt-mTOR Signaling Pathway
The results showed that the axonal dendrites of neurons in the hippocampal CA1 area of rats exposed to maltol aluminum showed neuritic beading and the dendritic spines were reduced, which resulted in dose-dependent LTP inhibition and led to impaired learning and memory function in rats. Expand
Amyloid-β Processing in Aged S100B Transgenic Mice Is Sex Dependent
(1) Background: Calcium-binding protein S100B is involved in neuroregeneration but has also been associated with neurodegeneration. These contrasting effects may result from concentration or durationExpand


Protective effects of Ginkgo biloba leaf extract on aluminum-induced brain dysfunction in rats.
It is demonstrated that GbE is effective in improving the ability of spatial learning and memory of aluminum-intoxicated rats, due to a decreased expression of APP and caspase-3 in rat brain, resulting in a decrease in the production of insoluble fragments of Abeta-amyloid. Expand
Anti-amnestic properties of Ginkgo biloba extract on impaired memory function induced by aluminum in rats
GBE treatment attenuated neurotoxic effects of aluminum as evidenced by improving rats’ performance in passive avoidance and lowering brain AChE activity, and GBE may be a promising therapy ameliorating neurotoxicity of Aluminum as an environmental toxic agent. Expand
Erratum to: Neuroprotective Effect of Hesperidin on Aluminium Chloride Induced Alzheimer’s Disease in Wistar Rats
It is concluded that hesperidin can reverse memory loss caused by aluminum intoxication through attenuating AChE activity and amyloidogenic pathway. Expand
Protective Effect of Centella asiatica against Aluminium-Induced Neurotoxicity in Cerebral Cortex, Striatum, Hypothalamus and Hippocampus of Rat Brain- Histopathological, and Biochemical Approach
Results of the study demonstrate neuroprotective potential of CA against AlCl3- induced oxidative damage and cognitive dysfunction and attenuated on treatment with CA. Expand
Amentoflavone Ameliorates Aβ1–42-Induced Memory Deficits and Oxidative Stress in Cellular and Rat Model
Experimental evidence was provided that AF exerts a protective effect against Aβ1–42-induced neurotoxcicity by inducing Nrf2 antioxidant pathways via AMPK signaling activation, which provided experimental evidence that AF might provide a clinical benefit to patients with AD. Expand
Neuroprotective Role of Lazaroids Against Aluminium Chloride Poisoning
It is suggested that 21-aminosteroids (lazaroids), by attenuating LPO and mitochondrial dysfunction, holds a promise as an agent that can potentially reduce Al-induced adverse effects in brain. Expand
Neuroprotective effect of Manasamitra vatakam against aluminium induced cognitive impairment and oxidative damage in the cortex and hippocampus of rat brain
It was observed that the administration of MMV along with AlCl3 improves memory performance and antioxidant activity against Al-induced neurotoxicity in rats and thus can be used as a neuroprotective agent. Expand
Evaluating potential of curcumin loaded solid lipid nanoparticles in aluminium induced behavioural, biochemical and histopathological alterations in mice brain.
  • V. Kakkar, I. Kaur
  • Chemistry, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2011
Solid lipid nanoparticles of curcumin (C-SLNs) with enhanced BA were prepared and investigated its therapeutic role in alleviating behavioural, biochemical and histochemical changes upon oral administration of AlCl(3) in male Lacca mice, highlighting the potential of C- SLNs for treatment of AD. Expand
Further evidence of centrophenoxine mediated protection in aluminium exposed rats by biochemical and light microscopy analysis.
  • B. Nehru, P. Bhalla, A. Garg
  • Chemistry, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2007
The results indicate that centrophenoxine has an antioxidant potential and should be examined further in aluminium toxic conditions, which may help in better understanding its role in neuronal degeneration. Expand
Oxidative damage following chronic aluminium exposure in adult and pup rat brains.
  • B. Nehru, Priya Anand
  • Chemistry, Medicine
  • Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements
  • 2005
The results of the present study suggest that in rats, aluminium (100 mg/kg body weight) has a pro-oxidant effect and thus acts as a neurotoxin. Expand