Ginkgo biloba Extract Reduces Hippocampus Inflammatory Responses, Improves Cardiac Functions And Depressive Behaviors In A Heart Failure Mouse Model

@article{Zhang2019GinkgoBE,
  title={Ginkgo biloba Extract Reduces Hippocampus Inflammatory Responses, Improves Cardiac Functions And Depressive Behaviors In A Heart Failure Mouse Model},
  author={Li-jun Zhang and Jianyang Liu and Ying-Bin Ge and Meiyan Liu},
  journal={Neuropsychiatric Disease and Treatment},
  year={2019},
  volume={15},
  pages={3041 - 3050}
}
Background Depression has been shown to share an extremely high comorbidity with heart failure (HF). Ginkgo biloba extract (GBE) is a widely used traditional Chinese medicine in cardiac disease. However, its potential therapeutic effect on depressive symptoms following HF largely remains unknown. In this article, we aimed to investigate its effects in reducing depressive behaviors of a HF mouse model. Moreover, we also discussed whether its effects are associated with changes in neural… Expand
View PDF
9 Citations
Background Citations
2

9 Citations

Citation Type

Citation Type

Antidepressant-like effects of 1-methylnicotinamide in a chronic unpredictable mild stress model of depression
TLDR
It was found that a single injection of MNA displayed notable antidepressant-like potential in the FST and TST without affecting the locomotor activity of mice, and the usage of K252a fully blocked the antidepressant- like effects of M NA in theFST, TST and CUMS model of depression. Expand
Medicinal Plants in the Treatment of Depression: Evidence from Preclinical Studies.
TLDR
The purpose of this narrative review is to provide an update regarding medicinal plants from the year 2000 to the present to examine the therapeutic potential of these antidepressant-like plants in order to contribute to the development of new therapeutic methods to alleviate the tremendous burden that depression causes worldwide. Expand
Bilobalide Alleviated Dextran Sulfate Sodium-Induced Experimental Colitis by Inhibiting M1 Macrophage Polarization Through the NF-κB Signaling Pathway
TLDR
Results indicated that administration of bilobalide improved experimental colitis via inhibition of M1 macrophage polarization through the NF-κB signaling pathway and could act as a potential drug for the treatment of inflammatory bowel disease (IBD) in the not-too-distant future. Expand
Main Active Ingredients and Quality Standards for Oral G. biloba Preparations
  • 2021
Ginkgo (Ginkgo bi loba L.) is a perennial deciduous tree of the Ginkgoaceae family, and its seeds (ginkgo nut) and leaves have high medicinal values. G. biloba was fi rstly recorded in Materia Medica… Expand
Baicalin ameliorates chronic unpredictable mild stress-induced depression through the BDNF/ERK/CREB signaling pathway
TLDR
It is indicated that BA can improve cognitive functions and has antidepressant effects in mice, which may be associated with activation of the BDNF/ERK/CREB signaling pathway in the hippocampus. Expand
Chinese Expert Consensus on Clinical Application of Oral Ginkgo biloba Preparations (2020)
Mechanisms of action of herbal antidepressants
Pharmacologic treatments in preclinical tinnitus models with special focus on Ginkgo biloba leaf extract EGb 761®
TLDR
This review will give a brief overview about preclinical models, presenting the heterogeneity of tinnitus sub-types depending on the different inner ear and brain structures involved in tinnitis etiology and pathogenesis, and providing an extensive overview on preclinical drug-based therapeutic approaches that have been explored in various animal models. Expand
TCM Substances in Neuropsychopharmacotherapy

References

SHOWING 1-10 OF 50 REFERENCES
Antidepressant-like effects of ginseng fruit saponin in myocardial infarction mice.
TLDR
GFS has potential antidepressive effects and the mechanisms involve the regulation of 5-HT concentrations in the cortex and rescued depression-like behaviors in MI mice. Expand
Experimental heart failure causes depression-like behavior together with differential regulation of inflammatory and structural genes in the brain
TLDR
After induction of ischemic CHF, mice exhibited anhedonic behavior, decreased exploratory activity and interest in novelty, and cognitive impairment analogous to symptoms observed in humans with CHF and comorbid depression. Expand
Inflammation associated with chronic heart failure leads to enhanced susceptibility to depression
TLDR
The results suggest that long‐term CHF increases inflammatory responses in the central nervous system and leads to depression in Sus mice. Expand
Anti-Depressive Effectiveness of Baicalin In Vitro and In Vivo
TLDR
It is confirmed that BA possessed efficient antidepressant effects on depression, which was possibly related to the inhibition of HMGB1/TLR4/NF-κB pathways. Expand
Structural abnormality of the hippocampus associated with depressive symptoms in heart failure rats
TLDR
The present study has demonstrated for the first time that the structural abnormality of the ventral hippocampus is associated with depressive symptoms in HF rats. Expand
Ginkgobiloba Extract Prevents Female Mice from Ischemic Brain Damage and the Mechanism Is Independent of the HO1/Wnt Pathway
TLDR
Results suggest that EGb 761 prevented brain damage in OVX female mice by improving grip strength and neurological deficits, and the mechanism of action is not through HO1/Wnt but via blocking the extrinsic apoptotic pathway. Expand
GC–MS-based metabolomic study on the antidepressant-like effects of diterpene ginkgolides in mouse hippocampus
TLDR
DG has antidepressant-like activities in mice and shed light on the biological mechanisms underlying the effects of diterpene ginkgolides on behavior, providing an important drug candidate for the treatment of depression. Expand
Ginkgo biloba: indications, mechanisms, and safety.
TLDR
Ginkgo biloba special extract (EGb761) is used in most randomized control trials and Mechanisms of action include increasing cerebral blood flow, antioxidant and antiinflammatory effects, with antiplatelet effects attributed to flavone and terpene lactones. Expand
Cardioprotective activity of Ginkgo biloba Phytosomes in isoproterenol-induced myocardial necrosis in rats: a biochemical and histoarchitectural evaluation.
  • Vandana Panda, S. Naik
  • Chemistry, Medicine
  • Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie
  • 2008
TLDR
The present findings have demonstrated that the cardioprotective effects of GBP in ISO-induced oxidative damage may be due to an augmentation of the endogenous antioxidants and inhibition of lipid peroxidation of membrane. Expand
Increased cardiac endothelin-1 and nitric oxide in adriamycin-induced acute cardiotoxicity: protective effect of Ginkgo biloba extract.
TLDR
The cardioprotective effects of EGb761 on markers of ADR-induced acute cardiotoxicity appeared to have been mediated by the regulation of inflammatory and vasoactive mediators, as well as the inhibition of membrane lipid peroxidation. Expand
...
1
2
3
4
5
...