Ginkgo biloba Extract (GbE) Stimulates the Hypothalamic Serotonergic System and Attenuates Obesity in Ovariectomized Rats

@article{Banin2017GinkgoBE,
  title={Ginkgo biloba Extract (GbE) Stimulates the Hypothalamic Serotonergic System and Attenuates Obesity in Ovariectomized Rats},
  author={Renata Mancini Banin and Iracema Senna de Andrade and Suzete Maria Cerutti and Lila Missae Oyama and M{\^o}nica Marques Telles and Eliane Beraldi Ribeiro},
  journal={Frontiers in Pharmacology},
  year={2017},
  volume={8}
}
Menopause is associated with increased risk to develop obesity but the mechanisms involved are not fully understood. We have shown that Ginkgo biloba extract (GbE) improved diet-induced obesity. Since GbE might be effective in the treatment of obesity related to menopause, avoiding the side effects of hormone replacement therapy, we investigated the effect of GbE on hypothalamic systems controlling energy homeostasis. Wistar rats were either ovariectomized (OVX) or Sham-operated. After 2 months… Expand
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References

SHOWING 1-10 OF 64 REFERENCES
Beneficial effects of Ginkgo biloba extract on insulin signaling cascade, dyslipidemia, and body adiposity of diet-induced obese rats
  • R. M. Banin, B. Hirata, +9 authors M. Telles
  • Medicine
  • Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
  • 2014
TLDR
GbE treatment significantly reduced food intake and body adiposity while it protected against hyperglycemia and dyslipidemia in diet-induced obesity rats, and enhanced insulin sensitivity in comparison to HFD+V rats, while it restored insulin-induced Akt phosphorylation, increased IRS-1, and reduced PTP-1B levels in gastrocnemius muscle. Expand
Ginkgo biloba Extract Improves Insulin Signaling and Attenuates Inflammation in Retroperitoneal Adipose Tissue Depot of Obese Rats
TLDR
The data suggest that GbE might have potential as a therapy to treat obesity-related metabolic diseases, with special interest to treat obese subjects resistant to adhere to a nutritional education program. Expand
Impairment of the serotonergic control of feeding in adult female rats exposed to intra-uterine malnutrition
TLDR
Female rats undernourished in utero had normophagic obesity as adults but had an absence of serotonin-induced hypophagia and low hypothalamic levels of the 5-HT2C receptor, and compensatory adaptations for the functional serotonergic impairment were evidenced. Expand
The anorectic effect of fenfluramine is increased by estradiol treatment in ovariectomized rats
TLDR
Investigation of the effects of 1 mg/kg d-fenfluramine and saline vehicle on food intake and wheel running in ovariectomized rats following estradiol benzoate (EB) and oil vehicle treatment concluded that EB's ability to increase the anorectic effect of this dose of fenfluramines appears behaviorally specific. Expand
Estradiol Valerate and Remifemin ameliorate ovariectomy-induced decrease in a serotonin dorsal raphe-preoptic hypothalamus pathway in rats.
  • Wenjuan Wang, Guangxia Cui, +5 authors W. Bai
  • Biology, Medicine
  • Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft
  • 2016
TLDR
Serotonin pathway is changed after ovariectomy, including the serotonin synthesis in DR and serotonin fibers in PO/AH, both E and Remifemin have an equivalent therapeutic effect on it. Expand
Ginkgo biloba extract (EGb761) influences monoaminergic neurotransmission via inhibition of NE uptake, but not MAO activity after chronic treatment.
TLDR
It is confirmed that the norepinephrine (NET), the serotonin (SERT), the dopamine (DAT) uptake transporters and MAO activity are inhibited by EGb761 in vitro, although rather high concentrations are required for inhibition of MAO-A andMAO-B activity. Expand
Lateral hypothalamic serotonergic responsiveness to food intake in rat obesity as measured by microdialysis.
TLDR
Examination of the serotonergic response stimulated by food ingestion in two different models of obesity indicates that the energy homeostasis disturbances of both these obesity models may not be ascribed to an impairment of the acute lateral hypothalamic serotonin response to a dietary stimulus and proves that 5HT in the lateral hypothalamus is important in the normal response to feeding. Expand
Effect of leptin on the acute feeding-induced hypothalamic serotonergic stimulation in normal rats
TLDR
Observations indicate that leptin probably interacts with the serotonergic-stimulating mechanisms elicited by food intake, intensifying them and may be significant for the hormone effects on energy balance. Expand
Adrenalectomy abolishes the food-induced hypothalamic serotonin release in both normal and monosodium glutamate-obese rats
TLDR
It is demonstrated that glucocorticoids are necessary for food intake to acutely stimulate 5-HT release and indicates that serotonergic activity in the LH is not likely to participate in the adrenalectomy-induced attenuation of the MSG-obesity. Expand
Antiestrogenic activities of Ginkgo biloba extracts
  • S. Oh, K. Chung
  • Medicine
  • The Journal of Steroid Biochemistry and Molecular Biology
  • 2006
TLDR
GBE has a biphasic effect on estrogen, and can be considered as a potential alternative to HRT with chemopreventive effects on breast cancer, however, further studies on animals and humans will be required. Expand
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