Ginkgo biloba Extract (GbE) Stimulates the Hypothalamic Serotonergic System and Attenuates Obesity in Ovariectomized Rats

  title={Ginkgo biloba Extract (GbE) Stimulates the Hypothalamic Serotonergic System and Attenuates Obesity in Ovariectomized Rats},
  author={Renata Mancini Banin and Iracema Senna de Andrade and Suzete M Cerutti and Lila Missae Oyama and M{\^o}nica Marques Telles and Eliane Beraldi Ribeiro},
  journal={Frontiers in Pharmacology},
Menopause is associated with increased risk to develop obesity but the mechanisms involved are not fully understood. We have shown that Ginkgo biloba extract (GbE) improved diet-induced obesity. Since GbE might be effective in the treatment of obesity related to menopause, avoiding the side effects of hormone replacement therapy, we investigated the effect of GbE on hypothalamic systems controlling energy homeostasis. Wistar rats were either ovariectomized (OVX) or Sham-operated. After 2 months… 

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  • Biology, Medicine
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
  • 2014
GbE treatment significantly reduced food intake and body adiposity while it protected against hyperglycemia and dyslipidemia in diet-induced obesity rats, and enhanced insulin sensitivity in comparison to HFD+V rats, while it restored insulin-induced Akt phosphorylation, increased IRS-1, and reduced PTP-1B levels in gastrocnemius muscle.

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Female rats undernourished in utero had normophagic obesity as adults but had an absence of serotonin-induced hypophagia and low hypothalamic levels of the 5-HT2C receptor, and compensatory adaptations for the functional serotonergic impairment were evidenced.

The anorectic effect of fenfluramine is increased by estradiol treatment in ovariectomized rats

Estradiol Valerate and Remifemin ameliorate ovariectomy-induced decrease in a serotonin dorsal raphe-preoptic hypothalamus pathway in rats.

Lateral hypothalamic serotonergic responsiveness to food intake in rat obesity as measured by microdialysis.

Examination of the serotonergic response stimulated by food ingestion in two different models of obesity indicates that the energy homeostasis disturbances of both these obesity models may not be ascribed to an impairment of the acute lateral hypothalamic serotonin response to a dietary stimulus and proves that 5HT in the lateral hypothalamus is important in the normal response to feeding.

Effect of leptin on the acute feeding-induced hypothalamic serotonergic stimulation in normal rats

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    The Journal of Steroid Biochemistry and Molecular Biology
  • 2006