Ginkgo biloba Extract (GbE) Stimulates the Hypothalamic Serotonergic System and Attenuates Obesity in Ovariectomized Rats

@article{Banin2017GinkgoBE,
  title={Ginkgo biloba Extract (GbE) Stimulates the Hypothalamic Serotonergic System and Attenuates Obesity in Ovariectomized Rats},
  author={Renata Mancini Banin and Iracema Senna de Andrade and Suzete Maria Cerutti and Lila Missae Oyama and M{\^o}nica Marques Telles and Eliane Beraldi Ribeiro},
  journal={Frontiers in Pharmacology},
  year={2017},
  volume={8}
}
Menopause is associated with increased risk to develop obesity but the mechanisms involved are not fully understood. We have shown that Ginkgo biloba extract (GbE) improved diet-induced obesity. Since GbE might be effective in the treatment of obesity related to menopause, avoiding the side effects of hormone replacement therapy, we investigated the effect of GbE on hypothalamic systems controlling energy homeostasis. Wistar rats were either ovariectomized (OVX) or Sham-operated. After 2 months… Expand
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Ginkgo biloba extract (GbE) attenuates obesity and anxious/depressive-like behaviours induced by ovariectomy
TLDR
GbE therapy was effective in attenuating the deleterious effects of ovariectomy on body composition, lipid profile, and anxious/depressive-like behaviours and further studies are warranted to better understand the therapeutic potential of GbE in menopause. Expand
Ginkgo biloba Extract (GbE) Restores Serotonin and Leptin Receptor Levels and Plays an Antioxidative Role in the Hippocampus of Ovariectomized Rats.
TLDR
The results suggest that GbE activity might improve menopausal-related hippocampal disorders, offering an alternative therapeutic tool particularly for women to whom hormone replacement therapy may be contraindicated. Expand
Ginkgo biloba Extract Modulates the Retroperitoneal Fat Depot Proteome and Reduces Oxidative Stress in Diet-Induced Obese Rats
TLDR
It was concluded that GbE acts as an antioxidant agent, and improved the proteome profile and oxidative stress response in the adipose tissue of diet-induced obese rats. Expand
Potential Anti-obesogenic Effects of Ginkgo biloba Observed in Epididymal White Adipose Tissue of Obese Rats
TLDR
GbE supplementation was effective in reducing energy intake in obese rats compared to the saline-treated placebo group and significantly reduced acetate accumulation and tended to reduce [3H]-oleate incorporation, into epididymal adipose tissue, suggesting a potentially anti-obesogenic effect in longer term therapies. Expand
Relationship between Dopamine and Serotonin on the Effect of Ginkgo biloba Extract in the Treatment of Obsessive Compulsive Disorder in Rodents
In this study, the effect of EGb-761, the standardized extract of Ginkgo biloba at dose levels of 50, 100 and 200 mg/kg was investigated on experimental models of obsessive compulsive disorder such… Expand
Metformin ameliorates body mass gain and early metabolic changes in ovariectomized rats
TLDR
The results suggest that metformin ameliorates the early alterations of metabolic parameters and rescues hepatic AMPK phosphorylation and ACC inactivation observed in ovariectomized rats. Expand
High-fat diet intake induces depressive-like behavior in ovariectomized rats
TLDR
The data indicate that the vulnerability to develop depression after menopause is influenced by high-fat intake, suggested that weight management is a crucial issue in postmenopausal women, probably having a beneficial role in preventing the appearance of mental health problems. Expand
Pyrogallol-Phloroglucinol-6,6’-Bieckol from Ecklonia cava Improved Blood Circulation in Diet-Induced Obese and Diet-Induced Hypertension Mouse Models
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Pyrogallol-phloroglucinol-6,6-bieckol (PPB) was found to significantly improve blood circulation, including a reduction of adhesion molecule expression, endothelial cell (EC) death, excessive vascular smooth muscle cell proliferation and migration, blood pressure, and lipoprotein and cholesterol levels. Expand
Potential effets of ginkgo (Ginkgo biloba, L.) on female reproduction.
TLDR
Ginkgo and its molecules, ginkgolide B and allopregnenolone can be useful for prevention and treatment of reproduction-related disorders like ovarian cancer, ovarian ischemia and menopausal syndrome and its constituents amifostine, leuprorelin, quercetin and kaempherol could be potentially applicable as biostimulators of female reproductive processes in human and veterinary medicine and animal production. Expand
Bioactive natural products for the prevention and treatment of diabetes mellitus
TLDR
Ginkgo biloba extract, epigallocatechin-3-gallate, genistein, resveratrol, and curcumin are among the main effective bioactive products studied due to their antiinflammatory and antioxidant effects and beneficial actions on lipid profile and glucose homeostasis. Expand
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