Gingerol, isoproterenol and ouabain normalize impaired post-rest behavior but not force-frequency relation in failing human myocardium.

@article{Maier2000GingerolIA,
  title={Gingerol, isoproterenol and ouabain normalize impaired post-rest behavior but not force-frequency relation in failing human myocardium.},
  author={Lars Siegfried Maier and Ch. Schwan and Wolfgang Schillinger and Kenichiro Minami and Ulrich Schuett and Burkert Pieske},
  journal={Cardiovascular research},
  year={2000},
  volume={45 4},
  pages={
          913-24
        }
}
OBJECTIVE Rest- and stimulation frequency-dependent potentiation of contractile force is blunted in failing human myocardium. These alterations have been related to reduced sarcoplasmic reticulum (SR) Ca(2+)-reuptake and enhanced transsarcolemmal Ca(2+)-elimination by Na+/Ca(2+)-exchange. We investigated whether inotropic interventions that enhance SR Ca(2+)-uptake, or reduce Ca(2+)-elimination by Na+/Ca(2+)-exchange, normalize impaired post-rest and force-frequency behavior in left ventricular… CONTINUE READING
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