Corpus ID: 36896086

Ginger Extract Defies Changes In Brain Serotonin Levels and Enzymes of Monoamine Metabolism During Withdrawal Following Chronic Ethanol Ingestion

  title={Ginger Extract Defies Changes In Brain Serotonin Levels and Enzymes of Monoamine Metabolism During Withdrawal Following Chronic Ethanol Ingestion},
  author={Swaroopa Marella and Kesireddy Sathyavelu Reddy},
In this study, the ameliorative effects of ginger extract on catecholamine metabolism were investigated in different brain regions of male wistar rats 72h post chronic ethanol (EtOH) ingestion. Main methods:Ethanol (2% w/v) was administered to rats by orogastric intubation. Biochemical investigation was performed for monoamine metabolising enzymes in five groups: (i) Control, (ii) EtOH treated, (iii) EtOH treated along with ginger extract (iv) Ethanol withdrawal (EW) and (v) EtOH withdrawal… Expand

Tables from this paper

A review of the effect of Ginger in inflammation
Ginger extract with the antioxidant and anti-inflammatory ingredients such as 6 Gingerols, 6-Shogoals, Zhingerol, and etc can reduces inflammatory factors through their effects on inflammatory, antioxidant, and serotonin mechanisms, reducing enzyme antioxidant and useful in reducing inflammatory disease and its complications, and treatment. Expand
The effects of ginger supplementation on inflammatory, antioxidant, and periodontal parameters in type 2 diabetes mellitus patients with chronic periodontitis under non-surgical periodontal therapy. A double-blind, placebo-controlled trial
It is recommended that ginger supplementation along with NSPT may be effective in the improvement of inflammation, oxidative, and periodontal status in T2DM with CP. Expand
DMSO_A_214333 1751..1761
1Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; 2Department of Nutrition, School of Allied Medical Sciences, Ahvaz JundishapurExpand


Neuroprotective evaluation of extract of ginger (Zingiber officinale) root in monosodium glutamate-induced toxicity in different brain areas male albino rats.
  • A. Waggas
  • Medicine
  • Pakistan journal of biological sciences : PJBS
  • 2009
The ginger extract has a neuroprotective role against monosodium glutamate toxicity effect and increased in monoamine content in most of the tested brain areas at different time intervals. Expand
Dopaminergic and serotonergic alterations in the rat brain during ethanol withdrawal: association with behavioral signs.
The results suggest that the levels of DA, 5-HT and their metabolites are altered by ethanol withdrawal, and may suggest that DA and 5- HT may be involved in the first 6 h of ethanol withdrawal syndrome in rats. Expand
Effects of chronic ethanol treatment on monoamine levels in rat hippocampus and striatum.
Results indicate alterations in monoamines, mainly in the striatum, after chronic ethanol, which are influenced by dose and by the length of time after the last drug administration. Expand
Alcohol withdrawal-induced changes in brain biogenic amines in mice: Influence of the genotype
The differences in withdrawal effects the authors noted between the two strains may be linked to the specific chemical neuroanatomy of the strains, and could be implied in the well known variability of withdrawal induced behavior in man. Expand
Zingiber officinale Mitigates Brain Damage and Improves Memory Impairment in Focal Cerebral Ischemic Rat
The beneficial effect of ginger rhizome to protect against focal cerebral ischemia was demonstrated and the cognitive enhancing effect and neuroprotective effect occurred partly via the antioxidant activity of the extract. Expand
Ethanol enhances the release of dopamine and serotonin in the nucleus accumbens of HAD and LAD lines of rats.
The results indicate that (1) the ACC DA system is more sensitive than the ACC 5-HT system to intraperitoneal ethanol administration in both lines and (2) there is no evidence for a relationship between alcohol preference and sensitivity of the ACCDA and 5- HT systems to acute intra peritonealanol administration. Expand
Serotonergic and dopaminergic involvement in ethanol intake.
It is proposed that multiple neurotransmitters and hormones collectively orchestrate the reward profile of ethanol, ethanol being the conductor and every instrument/transmitter being able to play the reward tune to some degree, but not until all instruments are playing together the full reward symphony will be experienced. Expand
Ethanol Self-Administration Restores Withdrawal-Associated Deficiencies in Accumbal Dopamine and 5-Hydroxytryptamine Release in Dependent Rats
It is suggested that deficits in accumbal monoamine release may contribute to the negative affective consequences ethanol withdrawal and, thereby, motivate ethanol-seeking behavior in dependent subjects. Expand
Neurochemical correlates of tolerance and strain differences in the neurochemical effects of ethanol
It is demonstrated that genetically determined differences exist in the sensitivity of the dopaminergic systems of mice to ethanol, and suggested that central dopamine neurons may be important in the behavioral effects of ethanol. Expand
Effects of acute, chronic ethanol and withdrawal on dorsal raphe neurons: electrophysiological studies
The results indicate that, in spite of the widespread use of serotonin transmission potentiating agents in the treatment of alcoholism, neither acute nor withdrawal from chronic ethanol administration produces drastic effects on dorsal raphe neurons. Expand