Ginger (Zingiber officinale Rosc.), a dietary supplement, protects mice against radiation-induced lethality: mechanism of action.

@article{Jagetia2004GingerO,
  title={Ginger (Zingiber officinale Rosc.), a dietary supplement, protects mice against radiation-induced lethality: mechanism of action.},
  author={Ganesh Chandra Jagetia and Manjeshwar Shrinath Baliga and Ponemone Venkatesh},
  journal={Cancer biotherapy \& radiopharmaceuticals},
  year={2004},
  volume={19 4},
  pages={
          422-35
        }
}
The radioprotective effect of hydroalcoholic extract of ginger rhizome (Zingiber officinale; ZOE) was studied in mice administered 250 mg/kg ZOE orally using oral gavage once daily for 5 consecutive days before exposure to 6, 7, 8, 9, 10, or 11 Gy of gamma-radiation. The animals were monitored daily up to 30 days postirradiation for the development of symptoms of radiation sickness and mortality. Pretreatment of mice with ZOE reduced the severity of symptoms of radiation sickness and mortality… 
The therapeutic effects of Zingiber officinale extract on mice irradiated by 60 Co γ-ray
TLDR
The findings indicated that gingerol had the therapeutic effects on mice against hematopoietic suppression and anti-oxidative damage caused by irradiation.
THE PHYSIOLOGICAL IMPACT OF GINGER, ZINGIBER OFFICINALE AND BLACK SEED OIL, NIGELLA SATIVA L. AS MEDICINAL PLANTS IN GAMMA-IRRADIATED RATS -
TLDR
The radioprotective role of ginger extract and black seed oil as an antioxidant defense system inducer is revealed and treatment of irradiated rats with GE or BSO ameliorated the changed levels of antioxidants in comparison with the control levels.
Effects of Zingiber officinale extract on antioxidation and lipid peroxidation in mice after exposure to 60 Co-γ-ray
Zingber officinale extract (ZOE) has been demonstrated to protect mice against radiation-induced sickness and mortality. In this study, we investigated protective ability of ZOE against
Sharafeldin THE PHYSIOLOGICAL IMPACT OF GINGER , ZINGIBER OFFICINALE AND BLACK SEED OIL
The study reported the radioprotective effects of some herbal plants in rats exposed to gammaradiation. Male albino rats were treated orally with the ginger extract, GE (250 mg/kg) and black seed
Jamun, Syzygium cumini Linn. Skeels, increases the survival of mice whole body exposed to different doses of γ-radiation
TLDR
Oral administration of jamun extract for five continuous days protected mice against the radiationinduced sickness and increased the survival, and free radical scavenging and increase in glutathione and reduction in lipid peroxidation may have contributed to the observed radioprotection.
Zingiber officinale extract modulates γ-rays-induced immunosuppression in mice
TLDR
Findings indicated that ZOE has the regulatory effect against g-rays-induced immun-suppression by means of protecting DNA against the radiation.
Protective effect of Zingiber officinale extract on rat testis after cyclophosphamide treatment
TLDR
Although ginger extract could not change testis weight, malondialdehyde (MDA) and ROS, but antioxidant and testosterone levels in serum were increased significantly, these protective effects of ginger on rat testis after cyclophosphamide treatment could be attributed to the higher serum level of antioxidants.
Treatment of mice with leaf extract of jamun (syzygium cumini linn. skeels) protects against the radiationinduced damge in the intestinal mucosa of mice exposed to different doses of γ-radiation
TLDR
It is demonstrated that jamun extract protects the radiation-induced damage in the small intestine of mice and may be a useful to protect against the radiationinduced gastrointestinal damage.
Efficacy of Ginger (Zingiber officinale) in Ameliorating Streptozotocin-Induced Diabetic Liver Injury in Rats: Histological and Biochemical Studies
TLDR
Ginger as a natural safe Herbal medication can be used to support liver functions in diabetic status by lowering blood glucose, level, regained body weight and liver index to near normal values.
A Study Of The Cardiovascular Toxic Effects Of Zingiber Officinale (Ginger) In Adult Male Albino Rats And Its Possible Mechanisms Of Action
TLDR
Results revealed that ginger is a partial vasorelaxant as it produced a relaxant effect on rabbit's aortic strip procontracted with phenylephrine, while preincubation with L-nitroarginine methyl ester significantly attenuated the ginger-induced relaxation indicating that the vasodilator effect of ginger is partially mediated through nitric oxide synthesis or release from L-NAME.
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TLDR
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TLDR
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