Ginger—Mechanism of action in chemotherapy-induced nausea and vomiting: A review

  title={Ginger—Mechanism of action in chemotherapy-induced nausea and vomiting: A review},
  author={Wolfgang Marx and Karin Ried and Alexandra L. McCarthy and L. Vitetta and Avni Sali and Daniel Mckavanagh and Liz Isenring},
  journal={Critical Reviews in Food Science and Nutrition},
  pages={141 - 146}
ABSTRACT Despite advances in antiemetic therapy, chemotherapy-induced nausea and vomiting (CINV) still poses a significant burden to patients undergoing chemotherapy. Nausea, in particular, is still highly prevalent in this population. Ginger has been traditionally used as a folk remedy for gastrointestinal complaints and has been suggested as a viable adjuvant treatment for nausea and vomiting in the cancer context. Substantial research has revealed ginger to possess properties that could… 
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The mechanism of gingerols in the prevention of CINV is summarized and a preliminary prediction on the potential targets and signaling pathways using network pharmacology is provided, laying a foundation for further researches.
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Adjunct ginger therapy on standard nausea and vomiting prophylaxis protocol especially in day 1 has benefit in reducing an acute phase nausea in patients receiving a combined carboplatin-paclitaxel regimen, but the benefit on delayed phase nausea and vomit is still equivocal.


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Chemotherapy-induced nausea and vomiting (CINV) is a common side-effect of cytotoxic treatment. It continues to affect a significant proportion of patients despite the widespread use of antiemetic
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This critical paper will highlight current literature available relating to what is known regarding the development of mucositis, including the molecular mechanisms involved in inducing inflammation particularly with respect to the role of proinflammatory cytokines, as well as provide a detailed discussion of why it is essential to consider extensive research in the role.
Nausea and vomiting and cancer patients' quality of life: a discussion of Professor Selby's paper.
It is evident from the data presented above that nausea and vomiting are frequent side effects which are often persistent and distressing to patients and these symptoms should be included as part of the physical domain component of quality of life instruments used in cancer patients.
Delayed nausea and vomiting continue to reduce patients' quality of life after highly and moderately emetogenic chemotherapy despite antiemetic treatment.
CINV continues to adversely affect patients' QoL despite antiemetic therapy even after treatment with only moderately emetogenic chemotherapy regimens, and even in the subgroup of patients who do not experience nausea and vomiting during the first 24 hours.
Effect of ginger root on cyclooxygenase-1 and 15-hydroxyprostaglandin dehydrogenase expression in colonic mucosa of humans at normal and increased risk for colorectal cancer
  • Yan Jiang, D. Turgeon, S. Zick
  • Medicine, Biology
    European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation
  • 2013
Elevated tissue levels of prostaglandin E2, produced by cyclooxygenase (COX), are an early event in colorectal cancer (CRC). Data suggest the efficacy of nonsteroidal anti-inflammatory drugs, such as
Quality of life consequences of chemotherapy-induced emesis
The hypothesis that side-effects produced by chemotherapy and antiemetic therapy significantly contributed to changes in quality of life observed was supported.
Update on the Chemopreventive Effects of Ginger and its Phytochemicals
The mechanisms of ginger seem to be promising for cancer prevention; however, further clinical studies are warranted to assess the efficacy and safety of ginger.
Inhibitory effects of zingerone, a pungent component of Zingiber officinale Roscoe, on colonic motility in rats
It is suggested that zingerone might exert beneficial therapeutic effects on hypermotility-induced diarrhea by abrogating excessive gastrointestinal motility through direct action on smooth muscles.
Effect of ginger on gastric motility and symptoms of functional dyspepsia.
Ginger stimulated gastric emptying and antral contractions in patients with functional dyspepsia, but had no impact on gastrointestinal symptoms or gut peptides.
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