Gimap3 and Gimap5 cooperate to maintain T-cell numbers in the mouse.

  title={Gimap3 and Gimap5 cooperate to maintain T-cell numbers in the mouse.},
  author={Kouta Yano and Christine E. Carter and Naofumi Yoshida and Takaya Abe and Akiko Yamada and Takeshi Nitta and Naozumi Ishimaru and Kensuke Takada and Geoffrey W Butcher and Yousuke Takahama},
  journal={European journal of immunology},
  volume={44 2},
Gimap3 (IAN4) and Gimap5 (IAN5) are highly homologous GTP-binding proteins of the Gimap family. Gimap3 and Gimap5, whose transcripts are abundant in mature lymphocytes, can associate with antiapoptotic Bcl-2 family proteins. While it is established that Gimap5 regulates T-cell survival, the in vivo role of Gimap3 is unclear. Here we report the preparation and characteristics of mouse strains lacking Gimap3 and/or Gimap5. We found that the number of T cells was markedly reduced in mice deficient… CONTINUE READING


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