Gilles de la Tourette syndrome

  title={Gilles de la Tourette syndrome},
  author={Mary May Robertson and V. Eapen and Harvey S. Singer and Davide Martino and Jeremiah M. Scharf and Peristera Paschou and Veit Roessner and Douglas W. Woods and Marwan Hariz and Carol A. Mathews and Rudi {\vC}rn{\vc}ec and James Frederick Leckman},
  journal={Nature Reviews Disease Primers},
Gilles de la Tourette syndrome (GTS) is a childhood-onset neurodevelopmental disorder that is characterized by several motor and phonic tics. Tics usually develop before 10 years of age, exhibit a waxing and waning course and typically improve with increasing age. A prevalence of approximately 1% is estimated in children and adolescents. The condition can result in considerable social stigma and poor quality of life, especially when tics are severe (for example, with coprolalia (swearing tics… 
Networks in the Field of Tourette Syndrome
Both adequate clinical management of TS and TS-related research require multidisciplinary preferably international cooperation in larger groups or networks to address the multiple facets of this disorder and yield valid and useful data.
Refractory Gilles de la Tourette Syndrome—Many Pieces That Define the Puzzle
The scope of this paper is to present the current state-of-the-art regarding refractory GTS and indicate possible approaches to define it, and to discuss promising approaches to the treatment of individuals with refracted GTS.
Candidate Genes and Pathways Associated with Gilles de la Tourette Syndrome—Where Are We?
To understand the genetic components of GTS etiopathology, an extensive review of the literature is conducted, compiling the candidate susceptibility genes identified through various genetic approaches.
Genetic Studies of Tic Disorders and Tourette Syndrome.
The main purpose for this review will be to summarize the new genetic discoveries of TS based on novel genetic methods and strategies, such as genome-wide association studies (GWASs), whole exome sequencing (WES), and whole genome sequencing (wGS) and compare them with other major psychiatric disorders in order to understand the current status of TS genetics.
Tricky “Ticcy” Case: Tics/Tourette Syndrome with Co-occurring OCD
The case of a young man exemplifies the complex and evolving experience of individuals struggling with Tourette syndrome and related disorders, and his and his family’s stories provide a lesson in the natural history and diagnostic process of these neuropsychiatric conditions.
Tics and Tourette Syndrome
This chapter reviews the core clinical characteristic of tics and associated features including premonitory urges and contextual factors of tic expression and provides guidelines for diagnostic assessment of TS and co-occurring psychopathology.
Tourette syndrome or PANDAS—a case report
A case report of a 19-year-old adolescent Ukrainian female, with a history of anxiety disorder and OCD, who, despite TS remission during childhood, presented with new-onset motor and phonic tics after 1 month of severe tonsillitis.
Treatment options for tic disorders
The authors summarized the steps that clinicians should follow treating GTS patient, and found that the impact of the tics on a patients’ life should be the first step; different patients could present different levels of tolerance to the symptoms.


Tourette syndrome, associated conditions and the complexities of treatment.
  • M. Robertson
  • Psychology, Medicine
    Brain : a journal of neurology
  • 2000
It is suggested that TS is heterogeneous from a variety of standpoints including clinical presentation and psychopathology, and thus neuropharmacological responses and possibly even aetiological and genetic mechanisms are possible.
The genetic basis of Gilles de la Tourette Syndrome
  • P. Paschou
  • Biology
    Neuroscience & Biobehavioral Reviews
  • 2013
Antineuronal antibody status and phenotype analysis in Tourette's syndrome
  • D. MartinoG. Defazio M. Orth
  • Psychology, Biology
    Movement disorders : official journal of the Movement Disorder Society
  • 2007
A comorbid diagnosis of ADHD was significantly less frequent in GTS patients positive for the anti‐60 kDa antibody only, and ANeA status does not differentiate a specific phenotype of GTS.
Gilles de la Tourette syndrome and disruptive behavior disorders: prevalence, associations, and explanation of the relationships.
It is suggested that CD in the context of Gilles de la Tourette syndrome is related to the presence of attention deficit hyperactivity disorder, as well as, and importantly, a family history of aggressive and violent behavior and forensic encounters.
The Inheritance of Tourette Disorder: A review.