Gilgamesh Is Required for rutabaga-Independent Olfactory Learning in Drosophila

@article{Tan2010GilgameshIR,
  title={Gilgamesh Is Required for rutabaga-Independent Olfactory Learning in Drosophila},
  author={Ying Lin Cheryl Tan and Dinghui Yu and Jennifer Pletting and Ronald L. Davis},
  journal={Neuron},
  year={2010},
  volume={67},
  pages={810-820}
}
Cyclic AMP signaling in Drosophila mushroom body neurons, anchored by the adenylyl cyclase encoded by the rutabaga gene, is indispensable for olfactory memory formation. From a screen for new memory mutants, we identified alleles of the gilgamesh (gish) gene, which encodes a casein kinase Iγ homolog that is preferentially expressed in the mushroom body neurons. The gish-encoded kinase participates in the physiology of these neurons underlying memory formation since the mutant memory deficit was… CONTINUE READING
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