Gilbert syndrome and the development of antiretroviral therapy-associated hyperbilirubinemia.

@article{Rotger2005GilbertSA,
  title={Gilbert syndrome and the development of antiretroviral therapy-associated hyperbilirubinemia.},
  author={Margalida Rotger and Patrick Taff{\'e} and Gabriela Bleiber and Huldrych F Gunthard and Hansjakob Furrer and Pietro Vernazza and Henning Drechsler and Enos Bernasconi and Martin Rickenbach and Amalio Telenti},
  journal={The Journal of infectious diseases},
  year={2005},
  volume={192 8},
  pages={1381-6}
}
BACKGROUND Unconjugated hyperbilirubinemia results from Gilbert syndrome and from antiretroviral therapy (ART) containing protease inhibitors. An understanding of the interaction between genetic predisposition and ART may help to identify individuals at highest risk for developing jaundice. METHODS We quantified the contribution of UGT1A1*28 and ART to hyperbilirubinemia by longitudinally modeling 1386 total bilirubin levels in 96 human immunodeficiency virus (HIV)-infected individuals during… CONTINUE READING