Giant hypertrophic gastropathy (Ménétrier's disease): pharmacologic effects on protein leakage and mucosal ultrastructure.

@article{Kelly1982GiantHG,
  title={Giant hypertrophic gastropathy (M{\'e}n{\'e}trier's disease): pharmacologic effects on protein leakage and mucosal ultrastructure.},
  author={D. Kelly and L. Miller and J. Malagelada and K. A. Huizenga and H. Markowitz},
  journal={Gastroenterology},
  year={1982},
  volume={83 3},
  pages={
          581-9
        }
}
Seven patients with giant hypertrophic gastropathy participated in a gastric intubation perfusion study to investigate the route and mechanism of protein leakage associated with this disease. All patients had gastric tight junctions wider than those in healthy controls. Acute administration of propantheline bromide reduced gastric albumin leakage (-50.7%, p less than 0.05) and concurrently decreased width of tight junctions (p less than 0.05) in all patients. Another antisecretory agent… Expand
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