Giant cell tumour of bone

@article{Thomas2009GiantCT,
  title={Giant cell tumour of bone},
  author={David M. Thomas and Keith M. Skubitz},
  journal={Current Opinion in Oncology},
  year={2009},
  volume={21},
  pages={338–344}
}
Purpose of review Giant cell tumour of bone (GCT) is the most common benign bone tumour and afflicts a young population. Treatment options for patients with unresectable disease have remained fairly static for the past three decades. Recent findings Recent discoveries have identified a key role for the osteoclast differentiation factor, receptor activator of nuclear factor kappa B (NF-κB) ligand (RANKL), in the genesis of GCT. The development of the fully human monoclonal antibody to RANKL… 
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TLDR
A phase II study in adults with GCTs has demonstrated significant clinical response to the antiRANKL monoclonal antibody denosumab, which is used in the treatment of postmenopausal osteoporosis, in which there is a state of increased bone resorption.
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In patients with both resectable and unresectable primary aggressive, recurrent, or metastatic GCT disease, systemic bisphosphonate and denosumab demonstrated good efficacy with decreased rates of disease progression and recurrence.
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TLDR
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Denosumab treatment of patients with GCTB significantly reduced or eliminated RANK-positive tumor giant cells and reduced the relative content of proliferative, densely cellular tumor stromal cells, replacing them with nonproliferative, differentiated, densely woven new bone.
Denosumab as a Treatment Alternative for Central Giant Cell Granuloma: A Long-Term Retrospective Cohort Study.
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A role for the RANK pathway in the pathogenesis of GCT and a potential therapeutic effect on tumor growth from denosumab, a fully human monoclonal antibody against RANKL are suggested.
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TLDR
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TLDR
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TLDR
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