Giant-cell tumor of the tendon sheath is an extra articular, localized, solitary, firm, benign, soft tissue tumor that usually presents with painless swelling for several years. Although giant cell tumors (GCT) are considered benign and have a good prognosis, they have a high risk of recurrence. Its overall incidence is 1 in 50,000 individuals and usually affects people between 30 to 50 years. The female to male ratio is 3:2. Etiology of the disease is unknown; it typically affects small joints of hands and feet. Complete local excision is the treatment of choice but local recurrence after excision is approximately 10% to 20%. We report a case of giant cell tumor of tendon sheath of hand presenting clinically as De’Quervains Tenosynovitis.