Giant cell glioblastoma in the cerebrum of a Pembroke Welsh corgi.

  • D K Giri, F Aloisio, +4 authors Brian Porter
  • Published 2011 in Journal of comparative pathology


A 6-year-old, neutered female Pembroke Welsh corgi was presented with a 1-month history of ataxia and panting. The clinical signs progressed until the dog became anorexic, obtunded and exhibited circling to the left. At necropsy examination, a mass was detected in the left forebrain, impinging on the cribriform plate. Microscopically, the mass was composed of sheets of round to pleomorphic neoplastic cells with vacuolated cytoplasm. Nuclear atypia, anisocytosis and anisokaryosis were common. Numerous bizarre, multinucleated giant cells containing 60 or more nuclei and giant mononuclear cells were present. The matrix contained abundant reticulin. Immunohistochemistry revealed the neoplastic cells uniformly to express vimentin, and a small number of neoplastic cells expressed glial fibrillary acid protein. A diagnosis of giant cell glioblastoma was made. Although well recognized in man, this tumour has been documented rarely in the veterinary literature.

DOI: 10.1016/j.jcpa.2010.10.008

Cite this paper

@article{Giri2011GiantCG, title={Giant cell glioblastoma in the cerebrum of a Pembroke Welsh corgi.}, author={D K Giri and F Aloisio and Dharani K. Ajithdoss and A Ambrus and J A Lidbury and H{\'e}ber E Hein and Brian Porter}, journal={Journal of comparative pathology}, year={2011}, volume={144 4}, pages={324-7} }