Giant cell arteritis. Epidemiology, etiology and pathogenesis.

  title={Giant cell arteritis. Epidemiology, etiology and pathogenesis.},
  author={Claes Nordborg and Elisabeth Nordborg and V. Petursdottir},
  journal={APMIS : acta pathologica, microbiologica, et immunologica Scandinavica},
  volume={108 11},
Giant cell arteritis (GCA) is a chronic inflammatory disorder targeting large and medium-sized arteries, which predominantly affects postmenopausal women. Its high incidence in populations with Scandinavian lineage, some familial accumulation, and the association with the HLA-DR4 haplotype indicate a genetic predisposition. Epidemiological observations, as well as the symptomatology, may indicate an infectious origin, but so far GCA has not been shown to be a truly infectious form of vasculitis… CONTINUE READING
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