Gi alpha 1-mediated cardiac electrophysiological remodeling and arrhythmia in hypertrophic cardiomyopathy.

@article{Ruan2007GiA1,
  title={Gi alpha 1-mediated cardiac electrophysiological remodeling and arrhythmia in hypertrophic cardiomyopathy.},
  author={Hongmei Ruan and Scherise Mitchell and Monika Vainoriene and Qing Lou and Lai-hua Xie and Shuxun Ren and Joshua I. Goldhaber and Yibin Wang},
  journal={Circulation},
  year={2007},
  volume={116 6},
  pages={596-605}
}
BACKGROUND Cardiac hypertrophy is a major risk factor for arrhythmias and sudden cardiac death. However, the underlying signaling mechanisms involved in the induction of arrhythmia and electrophysiological remodeling in cardiac hypertrophy are unclear. METHODS AND RESULTS Using an inducible gene-switch approach, we achieved tissue-specific and temporally regulated induction of a well-established hypertrophic pathway, the Ras-Raf-mitogen-activated protein kinases pathway, in adult mouse heart… CONTINUE READING