Gi Proteins Regulate Adenylyl Cyclase Activity Independent of Receptor Activation

@inproceedings{Melsom2014GiPR,
  title={Gi Proteins Regulate Adenylyl Cyclase Activity Independent of Receptor Activation},
  author={Caroline Bull Melsom and \Oivind \Orstavik and J Osnes and Tor Skomedal and Finn Olav Levy and Kurt Allen Krobert},
  booktitle={PloS one},
  year={2014}
}
BACKGROUND AND PURPOSE Despite the view that only β2- as opposed to β1-adrenoceptors (βARs) couple to G(i), some data indicate that the β1AR-evoked inotropic response is also influenced by the inhibition of Gi. Therefore, we wanted to determine if Gi exerts tonic receptor-independent inhibition upon basal adenylyl cyclase (AC) activity in cardiomyocytes. EXPERIMENTAL APPROACH We used the Gs-selective (R,R)- and the Gs- and G(i)-activating (R,S)-fenoterol to selectively activate β2ARs (β1AR… CONTINUE READING

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