Ghrelin suppresses noradrenaline release in the brown adipose tissue of rats.

@article{ManoOtagiri2009GhrelinSN,
  title={Ghrelin suppresses noradrenaline release in the brown adipose tissue of rats.},
  author={Asuka Mano-Otagiri and Hisayuki Ohata and Azusa Iwasaki-Sekino and Takahiro Nemoto and Tamotsu Shibasaki},
  journal={The Journal of endocrinology},
  year={2009},
  volume={201 3},
  pages={341-9}
}
To clarify the role of ghrelin in the regulatory mechanism of energy metabolism, we analyzed the effects of centrally and peripherally administered ghrelin on noradrenaline release in the brown adipose tissue (BAT) of rats using a microdialysis system. I.c.v. administration of ghrelin at a dose of 500 pmol suppressed noradrenaline release in BAT, and microinjection of ghrelin (50 pmol) into the paraventricular nucleus (PVN) or arcuate nucleus (ARC) of the hypothalamus also suppressed… CONTINUE READING

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Ghrelin is an orexigenic and metabolic signaling peptide in the arcuate and paraventricular nuclei.

American journal of physiology. Regulatory, integrative and comparative physiology • 2005
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