Ghrelin regulates hypothalamic prolyl carboxypeptidase expression in mice.

Abstract

Hypothalamic Prolyl carboxypeptidase (PRCP) plays a role in the regulation of energy metabolism by inactivating hypothalamic α-melanocyte stimulating hormone (α-MSH) levels and thus affecting melanocortin signaling. Alpha-MSH production is highly regulated both at transcriptional and posttranslational levels. Here we show that fasting induces a hypothalamic… (More)
DOI: 10.1016/j.molmet.2013.01.002

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