Ghrelin receptor (GHS-R1A) antagonism suppresses both operant alcohol self-administration and high alcohol consumption in rats.

@article{Landgren2012GhrelinR,
  title={Ghrelin receptor (GHS-R1A) antagonism suppresses both operant alcohol self-administration and high alcohol consumption in rats.},
  author={Sara Landgren and Jeffrey A. Simms and Petri Hyyti{\"a} and J{\"o}rgen A. Engel and Selena E Bartlett and Elisabet Jerlhag},
  journal={Addiction biology},
  year={2012},
  volume={17 1},
  pages={86-94}
}
The mechanisms involved in alcohol use disorders are complex. It has been shown that ghrelin is an important signal for the control of body weight homeostasis, preferably by interacting with hypothalamic circuits, as well as for drug reward by activating the mesolimbic dopamine system. The ghrelin receptor (GHS-R1A) has been shown to be required for alcohol-induced reward. Additionally, ghrelin increases and GHR-R1A antagonists reduce moderate alcohol consumption in mice, and a single… CONTINUE READING