Ghrelin receptor: high constitutive activity and methods for developing inverse agonists.

Abstract

The ghrelin receptor is a G protein-coupled receptor (GPCR) mainly distributed in the brain, and also expressed in peripheral tissues. Remarkably, the ghrelin receptor possesses a naturally high constitutive activity representing 50% of its maximal activity. Its endogenous ligand ghrelin is the only known orexigenic gastrointestinal peptide and plays a… (More)
DOI: 10.1016/B978-0-12-381296-4.00006-3

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Cite this paper

@article{Els2010GhrelinRH, title={Ghrelin receptor: high constitutive activity and methods for developing inverse agonists.}, author={Sylvia Els and Annette G Beck-Sickinger and Constance Chollet}, journal={Methods in enzymology}, year={2010}, volume={485}, pages={103-21} }